DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptpn18

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_038939136.1	Gene:	Ptpn18 / 301333	RGDID:	1311586	Length:	459	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	91/358 - (25%)
Similarity:	155/358 - (43%)	Gaps:	61/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 EARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQ 130
            ||||..        .|.|..|.|   .|::.: .|.:|.|...:.|..|       ::.|.:||:
  Rat    16 EARDHR--------EGAILAREF---SDIKAR-SVAWKTEGVCSTKAGS-------QQGNSKKNR 61

  Fly   131 NPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISA 195
            ....:|||..||:|..:......||:||:::.......|||.||||:..|:..:||:||:..:..
  Rat    62 YKDVVPYDETRVILSLLQEEGHGDYINANFIRGTDGSQAYIATQGPLPHTLLDFWRLVWEFGVKV 126

  Fly   196 IVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQL-ANFHIRTFRLYKMNEKQEVTDE 259
            |:|..:..:..:..|.:||....| ..|.|...|.:.:|..| |:..:||.::......:...:.
  Rat   127 ILMACQETENGRRKCERYWAQERE-PLQAGPFCITLTKETALTADITLRTLQVTFQKVPKGQKES 190

  Fly   260 RLILQFHYTEWYSHSCPFSNALLEFRRRVRLVVGNIIKDEDDMR-------GPILVHCSDGGGRS 317
            |.:.|..|..|..|..|.|:             .:|:...::.|       ||:.||||.|.||:
  Rat   191 RPVHQLQYMSWPDHGVPSSS-------------DHILTMVEEARCLQGLGPGPLCVHCSAGCGRT 242

  Fly   318 GVYMSIDANLELAEEEEC---FNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPV 379
            ||..::|...:|...:..   |::|..:.::|:.|...|:..|||:|:|.|:.:
  Rat   243 GVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQ----------- 296

  Fly   380 SELSDRLKAKARRNSGTKMNEYQAEYDQICKQT 412
                  |.::..:|:.......:.....|||.:
  Rat   297 ------LFSRTLQNNSPLYQNLKENRAPICKDS 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	72/253 (28%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Ptpn18	XP_038939136.1	PTP_DSP_cys	27..298	CDD:421693	80/312 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000