Protein Alignment Ptp36E and Ptprm

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001162103.1
• Gene: Ptprm / 29616
• RGDID: 620776
• Length: 1486
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 203/643 - (31%)
• Similarity: 335/643 - (52%)
• Gaps: 64/643 - (9%)

  Fly    45 PNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFPVL-------Y 102
            |:|.|              |.||.|        :|.....:...:::.||.:....:       :
  Rat   892 PHTYK--------------KREAAD--------VPYQTGQLHPAIRVADLLQHITQMKCAEGYGF 934

  Fly   103 KLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKP 167
            |.|:::..:.:|.....|.|..|..||:....|.||::||.|:.:.|...|||:|.:|:|...:|
  Rat   935 KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQMLEGDNSSDYINGNYIDGYHRP 999

  Fly   168 NAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIV 232
            |.||.||||::|||..:|||||.||.::|:|:|...:..:|.|.:|||.:.|:   |.||.:.::
  Rat  1000 NHYIATQGPMQETVYDFWRMVWYENTASIIMVTNLVEVGRVKCCKYWPDDTEI---YKDIKVTLI 1061

  Fly   233 REEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNII 296
            ..|.||.:.||||.:    ||:.:.:.|.|.|||:|.|..|..|: :..||.|.|:|:
  Rat  1062 DTELLAEYVIRTFAV----EKRGIHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK------- 1115

  Fly   297 KDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKF 361
            .......||::||||.|.||:|.::.||..|::||.|...:::..:::||..|..:|:..|||.|
  Rat  1116 SKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVF 1180

  Fly   362 IYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRA 426
            |:|.:.|..:||.|..|.|::........:.:..|..::.:.|:..:...||...:.||:.....
  Rat  1181 IHDAILEACLCGDTSIPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLP 1245

  Fly   427 DNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLV 491
            .|.||||.:..:|||...|:|.:..|.: ::|||:..:|.|.:|..:|||:.|:.:|:.:||.||
  Rat  1246 RNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1309

  Fly   492 YDQECSAVVVLCQPPSQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSL 556
            .|..|::||:| .....:|..|.:|| ::.:.::||: .|.:|.:           .:.:.|:|.
  Rat  1310 LDYHCTSVVML-NDVDPTQLCPQYWP-ENGVHRHGPI-QVEFVSA-----------DLEEDIISR 1360

  Fly   557 TEMMAGVKAPT---RTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVD--YGPVCVVSPD 616
            ...:.....|.   |.||.||...|||....|.|..|.:.|:..|:.|:.:.:  .|...|...:
  Rat  1361 IFRIYNASRPQDGHRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLN 1425

  Fly   617 GRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674
            |..|:|.:||.:...|.:.....||||.||||:|.::|.:|:.:.:||:||::.|.|:
  Rat  1426 GGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	95/243 (39%)
		Y_phosphatase	428..671	CDD:459674	79/247 (32%)
Ptprm	NP_001162103.1	MAM	22..182	CDD:214533
		ig	192..274	CDD:395002
		FN3	209..>638	CDD:442628
		fn3	499..574	CDD:394996
		R-PTPc-M-1	918..1190	CDD:350481	103/285 (36%)
		R-PTPc-M-2	1276..1481	CDD:350483	68/218 (31%)