DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptpn1

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_038960209.1	Gene:	Ptpn1 / 24697	RGDID:	61965	Length:	451	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	121/514 - (23%)
Similarity:	194/514 - (37%)	Gaps:	158/514 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 IPNGPI--------DIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKC 134
            :|..|.        ||||  :..|    ||                 ||.|....|..:|:....
  Rat    27 LPGSPSPSCLFIFPDIRH--EASD----FP-----------------CRIAKLPKNKNRNRYRDV 68

  Fly   135 IPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVML 199
            .|:|::|:.|.:    :|:||:|||.:.......:||:||||:..|...:|.|||::....:|||
  Rat    69 SPFDHSRIKLHQ----EDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVML 129

  Fly   200 TKTFDFAKVMCHQYWPPNMEVHEQYGD--IFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLI 262
            .:..:...:.|.||||...|....:.|  :.:.::.|:..:.:.:|...|    |.....:.|.|
  Rat   130 NRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLEL----ENLATQEAREI 190

  Fly   263 LQFHYTEWYSHSCPFSNA-LLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDAN 326
            |.||||.|.....|.|.| .|.|..:|| ..|::..:    .|||:||||.|.||||.:...|..
  Rat   191 LHFHYTTWPDFGVPESPASFLNFLFKVR-ESGSLSPE----HGPIVVHCSAGIGRSGTFCLADTC 250

  Fly   327 LELAEEEE---CFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKA 388
            |.|.::.:   ..::...|.::|:.|.||::..:|.:|.|..:.|
  Rat   251 LLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIE-------------------- 295

  Fly   389 KARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN 453
                  |.|                 |.:||  ...:...:|.:.:.|..||::..|
  Rat   296 ------GAK-----------------FIMGD--SSVQDQWKELSHEDLEPPPEHVPP-------- 327

  Fly   454 AFTDYINSVFVDGYTKPREYIVTEWPMKHTL-------GEFWS---LVYDQECSAVVVLCQPPSQ 508
                           .||       |.|.||       .|.:|   .|.::.|....:|.:..|:
  Rat   328 ---------------PPR-------PPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESR 370

  Fly   509 SQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPT 567
            :                 |..:||.:.|.|.      :.::.|::|......|....||
  Rat   371 A-----------------PSIAVHSMSSMSQ------DTEVRKRMVGGGLQSAQASVPT 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	76/248 (31%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	27/150 (18%)
Ptpn1	XP_038960209.1	PTPc-N1	38..311	CDD:350456	92/353 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910