DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptprq

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	391	Identity:	110/391 - (28%)
Similarity:	183/391 - (46%)	Gaps:	66/391 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSARYDDVEK------QQRKSRAIVSIPNTI-KLSMLNSGLLSFERIK----------------- 64
            :.:.|.|..|      .:|....|:|:...| .:.:|.:.:.:|.||:
Mouse  1886 TDSEYSDPIKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPRDAEII 1950

  Fly    65 --------------LEARDEN----NSLSKTIPNGPIDIRHFL----KLCDLRRKFPVLYKLEFQ 107
                          ||.:||.    .|..|:|.  |:..:.||    :||....   :.::.||.
Mouse  1951 DTKFKLDQLITVADLELKDERLTRLLSYRKSIK--PVSKKSFLQHVEELCTNNN---LKFQEEFS 2010

  Fly   108 TAAK-VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYI 171
            ...| ::..:...|....|..||:.|...||:.|||.|.....:..|||:|||||...|.||.:|
Mouse  2011 ELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADVSIPGSDYINASYVSGYLCPNEFI 2075

  Fly   172 VTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQ 236
            .||||:..||..:|||||:.....:||||:.|:..::.||||||.:.:....:|||.|..:.|:.
Mouse  2076 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDILITKLMEDI 2140

  Fly   237 LANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRLVVGNIIKDED 300
            ..::.||..::.:..      |...:.|.::|.|..|..|.:.. |:.|   |:||..:...|..
Mouse  2141 QIDWTIRDLKIERHG------DCMTVRQCNFTGWPEHGVPENTTPLIHF---VKLVRTSRAHDAT 2196

  Fly   301 DMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDT 365
                |::||||.|.||:||::::|...:...:.:..:::|.:.:||..|..:|:|:.||.|::..
Mouse  2197 ----PMVVHCSAGVGRTGVFIALDHLTQHIHDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQC 2257

  Fly   366 L 366
            :
Mouse  2258 I 2258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	83/243 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020
		fn3	399..>441	CDD:365830
		FN3	570..654	CDD:238020
		fn3	668..744	CDD:365830
		FN3	762..850	CDD:238020
		fn3	857..934	CDD:365830
		FN3	951..1049	CDD:238020
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589	8/41 (20%)
		R-PTPc-Q	2033..2256	CDD:350464	81/235 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810