DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp36E and Ptpru

DIOPT Version :9

Sequence 1:NP_001286033.1 Gene:Ptp36E / 35091 FlyBaseID:FBgn0267486 Length:682 Species:Drosophila melanogaster
Sequence 2:XP_011248512.1 Gene:Ptpru / 19273 MGIID:1321151 Length:1473 Species:Mus musculus


Alignment Length:575 Identity:180/575 - (31%)
Similarity:296/575 - (51%) Gaps:47/575 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 KKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLL------KPNAYIVTQ------ 174
            ||:.|:..:......||.:.|.|..:....|:||::|:|:|..:      :.|.:|.||      
Mouse   918 KKDKLKGGRQEPVSAYDRHHVKLHPMLADPDADYISANYIDIRINRQGYHRSNHFIATQGDLAQG 982

  Fly   175 -------GPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIV 232
                   ||..|.:..:|||||||..::|||:||..:..:|.|.:|||   |..:.||||.|.:|
Mouse   983 QAPSAPPGPKPEMIYDFWRMVWQEQCASIVMITKLVEVGRVKCSRYWP---EDSDMYGDIKITLV 1044

  Fly   233 REEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNII 296
            :.|.||.:.:|||.|    |::..:....:.|||:|.|..|..|: :..||.|.|||:       
Mouse  1045 KTETLAEYVVRTFAL----ERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVK------- 1098

  Fly   297 KDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKF 361
            .......|||::|||.|.||:|.|:.:|..|::||.|...:::..:|.|...|..:::..|||.|
Mouse  1099 ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF 1163

  Fly   362 IYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRA 426
            |:|.:.|..:||:|..||:|.....:...|.:..:..::.:.|:..:...||...:.:|:.....
Mouse  1164 IHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLP 1228

  Fly   427 DNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLV 491
            .||:|||.:..:|||...|:|.|..|:. .:|||:...|.||:...:|||..|::.|..:||.||
Mouse  1229 RNRDKNRSMDVLPPDRCLPFLISSDGDP-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1292

  Fly   492 YDQECSAVVVLCQPPSQSQQYP--SFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIV 554
            ||..|:::|:|.|....:..:|  .:||...: ::|| :..|.:|...:..::....|::...  
Mouse  1293 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGR-QQYG-LMEVEFVSGTANEDLVSRVFRVQNS-- 1353

  Fly   555 SLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRS 619
              :.:..|    ...|:.||...|......|.|..:.::|:..|:.|:.:...|...|...:|..
Mouse  1354 --SRLQEG----HLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESGDGRTVVHCLNGGG 1412

  Fly   620 RAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674
            |:|.:||....:|.:..|..||||.|.||:|.::|.:||.|.:|.:|||:.|.|:
Mouse  1413 RSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp36ENP_001286033.1 Y_phosphatase 125..368 CDD:395053 88/262 (34%)
Y_phosphatase 428..671 CDD:395053 76/244 (31%)
PtpruXP_011248512.1 MAM 31..194 CDD:214533
IG 204..290 CDD:214652
fn3 299..373 CDD:365830
FN3 394..489 CDD:238020
fn3 502..585 CDD:365830
PTP_DSP_cys 951..1174 CDD:391942 82/236 (35%)
R-PTPc-U-2 1259..1465 CDD:350485 64/215 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000829
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
54.770

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