DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptpre

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001303607.1	Gene:	Ptpre / 19267	MGIID:	97813	Length:	719	Species:	Mus musculus

Alignment Length:	677	Identity:	197/677 - (29%)
Similarity:	336/677 - (49%)	Gaps:	93/677 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KQQRKSRAIVS-----IPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNG-----PIDIRH 87
            ::|||  |:||     :||         |:|.      |...:...|....|:|     ||.:.|
Mouse    91 RKQRK--AVVSSNDKKMPN---------GILE------EQEQQRVMLLSRSPSGPKKFFPIPVEH 138

  Fly    88 F-----LKLCDLRRKFPVLYKLEFQTAAKVE-SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEK 146
            .     ::..|..::|    :.||.:..... ..|...|.|:.|.|||:.|..:|.|:.||:|.:
Mouse   139 LEEEIRVRSADDCKRF----REEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHCRVILSQ 199

  Fly   147 VGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH 211
            |.|:..|||:||||:|...:.|.:|..|||.:|||..:|||||::..:.|||||...:..:..|:
Mouse   200 VDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKERKEEKCY 264

  Fly   212 QYWPPNMEVHEQ----YGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDE----RLILQFHYT 268
            ||||      :|    ||:|.:.:.....|.::.||.|.::     .::.|.    ||:.|.|:|
Mouse   265 QYWP------DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIH-----PQLPDSCKAPRLVSQLHFT 318

  Fly   269 EWYSHSCPFSN-ALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEE 332
            .|.....||:. .:|:|.::|:.:       .....|||:||||.|.||:|.::.|||.:::...
Mouse   319 SWPDFGVPFTPIGMLKFLKKVKTL-------NPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHS 376

  Fly   333 EECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTK 397
            |:..:||.::.::|..|..:|:...||.|||..|.|:.:.|.|...||.|...|  :...::.|.
Mouse   377 EQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHL--QTLHSTATH 439

  Fly   398 MNEYQAEYD-------QICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAF 455
            .::...|.:       :|.|:..|       .|:...|.:|.|.:..:|.|..|..|:..:|..|
Mouse   440 FDKIGLEEEFRKLTNVRIMKENMR-------TGNLPANMKKARVIQIIPYDFNRVILSMKRGQEF 497

  Fly   456 TDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVL--CQPPSQSQQYPSFWPN 518
            |||||:.|:|||.:...::.|:.|:.||:.:||.:|::.:...:|:|  .|...|.:.| .:||.
Mouse   498 TDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCY-QYWPT 561

  Fly   519 KSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWP-MGH 582
            :..: .:|.:    .:..||.|..:  ...:...:|:..:.:|..:...|.|:.|....|| :|
Mouse   562 EGSV-THGDI----TIEIKSDTLSE--AISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVG- 618

  Fly   583 KVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVK 647
             :|:....::.|:..|:..:.:....|:.|....|..|.|.:.|.:..:|:|...|.:|||||||
Mouse   619 -IPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVK 682

  Fly   648 TVRRHRPQLVENMTEYKYCYDLVLHYV 674
            ::|..||.:|:.:.:|::||.:|..::
Mouse   683 SLRLQRPHMVQTLEQYEFCYKVVQDFI 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	89/251 (35%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	70/245 (29%)
Ptpre	NP_001303607.1	PTPc	154..412	CDD:214550	95/279 (34%)
		PTPc	180..412	CDD:238006	88/249 (35%)
		PTPc	444..707	CDD:214550	76/279 (27%)
		PTPc	472..707	CDD:238006	70/244 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48012
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870