DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptprd

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_036019731.1	Gene:	Ptprd / 19266	MGIID:	97812	Length:	1966	Species:	Mus musculus

Alignment Length:	702	Identity:	211/702 - (30%)
Similarity:	341/702 - (48%)	Gaps:	106/702 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EKQQRKSRAIVSIPNT-----------IKLSMLN--------------------SGLLSFERIKL 65
            |.:.|||    |:||:           ::|..||                    |.|.|  :...
Mouse  1310 ESESRKS----SLPNSKEVPSHHPTDPVELRRLNFQTPALSSNSVPYASLIGSVSSLSS--QTTT 1368

  Fly    66 EARDENNSLSKTIPNG-----PIDIRHFLKLCD----LRRKFPVLYKLEFQTAAKVESNTCRHAL 121
            ::..:||||.:....|     ||.|   |:|.|    |:....:.:..|:::....:..|..|:.
Mouse  1369 QSIYDNNSLPRFARKGMASHPPIPI---LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSN 1430

  Fly   122 KKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWR 186
            .:.|..||:....|.||::||:|..:.|:..||||||:|:|...|.||||.|||.:.||...:||
Mouse  1431 LEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWR 1495

  Fly   187 MVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYK-- 249
            |:|::..:.:||:||..:.::|.|.||||....  |.:|.:.:.::...:||.:.:|||.|||
Mouse  1496 MIWEQRSATVVMMTKLEERSRVKCDQYWPSRGT--ETHGLVQVTLLDTVELATYCVRTFALYKNG 1558

  Fly   250 MNEKQEVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDG 313
            .:||:||.      ||.:|.|..|..| .....|.|.|||:..      :..| .||::||||.|
Mouse  1559 SSEKREVR------QFQFTAWPDHGVPEHPTPFLAFLRRVKTC------NPPD-AGPMVVHCSAG 1610

  Fly   314 GGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFP 378
            .||:|.::.|||.||..:.|:..:::|::..:|..|..:|:..:||.||:|.|.|.:.||.|..|
Mouse  1611 VGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVP 1675

  Fly   379 VSELSDRLKAKARRNSGTKMNEYQAEYDQICK---QTPRFTIGD--CAGGHRADNREKNRDVLCV 438
            ...|...::...:..:|..:...:.|:.::..   .|.||...:  |       |:.|||.|..:
Mouse  1676 ARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPC-------NKFKNRLVNIM 1733

  Fly   439 PPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLC 503
            |.::.|..|...:|...:||||:.|:|||.:.:.||.|:.|:..|..:||.::::...:.||:|.
Mouse  1734 PYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT 1798

  Fly   504 QPPSQS-QQYPSFWP-NKSKMEKYGPVFSVHYVMSKSYTNIKQW---EFKINKKIVSLTEMMAGV 563
            :..... ::...:|| .:|...:|      ..|...:..|:.|:   |||:       |:...|
Mouse  1799 KLREMGREKCHQYWPAERSARYQY------FVVDPMAEYNMPQYILREFKV-------TDARDG- 1849

  Fly   564 KAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDY---GPVCVVSPDGRSRAGVYC 625
              .:|||:.||.|.|| ...||.|....:..:..|.  :.|..:   ||:.|....|..|.||:.
Mouse  1850 --QSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVH--KTKEQFGQDGPISVHCSAGVGRTGVFI 1909

  Fly   626 AANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF 677
            ..:..:|::...|.||:||.||.:|..||.:|:...:|::||...|.|:..|
Mouse  1910 TLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSF 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	94/245 (38%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	74/250 (30%)
Ptprd	XP_036019731.1	I-set	31..123	CDD:400151
		Ig strand A'	39..43	CDD:409353
		Ig strand B	46..55	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..72	CDD:409353
		Ig strand D	75..83	CDD:409353
		Ig strand E	84..94	CDD:409353
		Ig strand F	102..110	CDD:409353
		Ig strand G	113..123	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400
		Ig strand B	151..155	CDD:409400
		Ig strand C	164..168	CDD:409400
		Ig strand E	198..202	CDD:409400
		Ig strand F	212..217	CDD:409400
		Ig strand G	224..227	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401
		Ig strand B	261..265	CDD:409401
		Ig strand C	274..278	CDD:409401
		Ig strand E	295..299	CDD:409401
		Ig strand F	307..312	CDD:409401
		Ig strand G	320..323	CDD:409401
		FN3	331..420	CDD:238020
		FN3	427..519	CDD:238020
		FN3	524..612	CDD:238020
		FN3	620..714	CDD:238020
		FN3	721..827	CDD:238020
		FN3	832..927	CDD:238020
		FN3	930..1021	CDD:238020
		FN3	1031..>1092	CDD:238020
		R-PTPc-D-1	1388..1671	CDD:350472	106/300 (35%)
		R-PTP-D-2	1672..1963	CDD:350476	86/316 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810