DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptprc

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001104786.2	Gene:	Ptprc / 19264	MGIID:	97810	Length:	1293	Species:	Mus musculus

Alignment Length:	658	Identity:	197/658 - (29%)
Similarity:	317/658 - (48%)	Gaps:	95/658 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ERIKLEARDENNSLSKTIPNGPIDIRHFLKLCDLRRKFP---VLYKLEFQTAAKVESN-TCRHAL 121
            |:.:|..||:...|....|     |...:.|...:||..   .|:..|||:..:|.|. ..:.|.
Mouse   603 EQQELVERDDEKQLMDVEP-----IHSDILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDAR 662

  Fly   122 KKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWR 186
            |.:|..||:....:|||||||.|.::.|...|.|:||||:|...:|..||..|||.:|||..:||
Mouse   663 KPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWR 727

  Fly   187 MVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIR--TFRLYK 249
            |:|::..:.|||:|:..:..:..|.:|||...|....:.||.:.|       |.|.|  .:.:.|
Mouse   728 MIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFKDIVVTI-------NDHKRCPDYIIQK 785

  Fly   250 MN--EKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDEDDMRGPILVHCS 311
            :|  .|:|....|.:....:|.|..|..|.. :.||:.||||. ...|...      |||:||||
Mouse   786 LNVAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVN-AFSNFFS------GPIVVHCS 843

  Fly   312 DGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTW 376
            .|.||:|.|:.|||.||..|.|...:|:||:.|||:.|..:|:...||..|:..|.|:...|:|.
Mouse   844 AGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETE 908

  Fly   377 FPVSELSDRLKAKARRNSGTKMNEYQAEYDQICK----QTPRFTIGDCAGGHRADNREKNRDVLC 437
            ..:|||...|....:|:..:..:..:|||.::..    :|...       |::.:|::|||:...
Mouse   909 VNLSELHSCLHNMKKRDPPSDPSPLEAEYQRLPSYRSWRTQHI-------GNQEENKKKNRNSNV 966

  Fly   438 VPPDNFRPYL-----TSFQGNAFTD--------------YINSVFVDGYTKPREYIVTEWPMKHT 483
            ||.|..|..|     .|.:....:|              |||:.||..|.||...|..:.|:|.|
Mouse   967 VPYDFNRVPLKHELEMSKESEPESDESSDDDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKET 1031

  Fly   484 LGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSKMEKYGPVFSVHYVM-----SKSYTNIK 543
            :|:||.:::.::...:|:|.:..:..|:..:.:..:.| :.||   .:...|     :.:|| ::
Mouse  1032 IGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYWGEGK-QTYG---DMEVEMKDTNRASAYT-LR 1091

  Fly   544 QWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKV--- 605
            .:|.:.:|:           |.| |||..:|.|.| .|.::|:....||   :|::..:.|:
Mouse  1092 TFELRHSKR-----------KEP-RTVYQYQCTTW-KGEELPAEPKDLV---SMIQDLKQKLPKA 1140

  Fly   606 --------DYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTE 662
                    .:..:.|...||..:.|::||....:|.......|||||.||::|:.||.:|.:..:
Mouse  1141 SPEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGVVCSYEQ 1205

  Fly   663 YKYCYDLV 670
            |::.||::
Mouse  1206 YQFLYDII 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	94/247 (38%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	72/278 (26%)
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:372119
		Herpes_BLLF1	<27..>191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..174
		CD45	212..265	CDD:372194
		FN3	393..451	CDD:238020
		FN3	474..553	CDD:238020
		R-PTPc-C-1	696..896	CDD:350405	80/213 (38%)
		Substrate binding. /evidence=ECO:0000250	842..848		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1003		2/22 (9%)
		R-PTP-C-2	1006..1211	CDD:350406	59/225 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1240..1293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860