DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and Ptpn2

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001120649.1	Gene:	Ptpn2 / 19255	MGIID:	97806	Length:	406	Species:	Mus musculus

Alignment Length:	300	Identity:	100/300 - (33%)
Similarity:	151/300 - (50%)	Gaps:	31/300 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LSKTIPNGPIDIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKK--NNLEKNQNPKCIP 136
            :|.||.      |.|.:| |.:.::..|| ||.:.    ||:...|.:.|  .|..:|:.....|
Mouse     1 MSATIE------REFEEL-DAQCRWQPLY-LEIRN----ESHDYPHRVAKFPENRNRNRYRDVSP 53

  Fly   137 YDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTK 201
            ||::||.|:..    ::||:|||.||......:||:||||:..|...:|.||||:...|:|||.:
Mouse    54 YDHSRVKLQST----ENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNR 114

  Fly   202 TFDFAKVMCHQYWPPNME--VHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQ 264
            |.:...|.|.||||.:..  |.::.| ..:.::.|:..:.:.:...:|..:|    ..:.|.|..
Mouse   115 TVEKESVKCAQYWPTDDREMVFKETG-FSVKLLSEDVKSYYTVHLLQLENIN----TGETRTISH 174

  Fly   265 FHYTEWYSHSCPFSNA-LLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLE 328
            ||||.|.....|.|.| .|.|..:|| ..|.:..|    .||.::|||.|.||||.:..:|..|.
Mouse   175 FHYTTWPDFGVPESPASFLNFLFKVR-ESGCLTPD----HGPAVIHCSAGIGRSGTFSLVDTCLV 234

  Fly   329 LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE 368
            |.|:.|..||...|..:|:.|.||::..:|.:|.|..:.|
Mouse   235 LMEKGEDVNVKQLLLNMRKYRMGLIQTPDQLRFSYMAIIE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	84/245 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Ptpn2	NP_001120649.1	PTPc	5..274	CDD:214550	97/294 (33%)
		PTPc	45..274	CDD:238006	83/242 (34%)
		Substrate binding. /evidence=ECO:0000250	216..222		3/5 (60%)
		Endoplasmic reticulum location. /evidence=ECO:0000250	341..406
		Mediates interaction with STX17. /evidence=ECO:0000250	371..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910