DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and F36H12.10

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_500756.1	Gene:	F36H12.10 / 185396	WormBaseID:	WBGene00018124	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	98/386 - (25%)
Similarity:	161/386 - (41%)	Gaps:	69/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NSGLLSFERIKLEARDENNSLSKTIPNG------------PIDIRHFLKLCD-----LRRKFPVL 101
            |:.....:|:|.|.:.::...:|..|..            ||..:..|:..|     ||.:|..|
Worm    45 NTATEGSKRVKKEKKKDDGEAAKGDPTNKTNMTPAPPQTHPIVEQWVLRALDVGVDKLREEFRGL 109

  Fly   102 YKLEFQTAAKVESNTCRH---ALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDS 163
            .|.......:|..|..:.   |:.||   :.|:..|  .|.:.|.|::.   ...:|::|:||..
Worm   110 AKYTRPDMTQVMFNANQSPDIAITKN---RYQDVPC--QDLSAVKLDQP---SPCNYIHANYVGC 166

  Fly   164 LLKP-NAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWP--PNMEVHEQYG 225
            .:.| ..:|..|||:::|:..:|.||.|..:..||||.||.:..|:.|.||||  ...::..:.|
Worm   167 PMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSG 231

  Fly   226 DIFINIVRE---EQLANFHIRTFRL-YKMNEKQEVTDERLILQFHYTEWYSHSC-PFSNALLEFR 285
            .:..|:...   |:.....|....| |...:...|.      ...:|||..... |.....||..
Worm   232 CVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVR------HLQWTEWPDRGVPPCKLTSLELL 290

  Fly   286 RRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLE-LAEEEECFNVFGYLKKLRQSR 349
            ..:|   |:.:        ||:||||.|.||:|..::|:..|| :||.:.|..:...:|.||..|
Worm   291 SAIR---GSKV--------PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQR 344

  Fly   350 KGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICK 410
            ...::|..||.||:..:..:.:            ::.|.|   .:.....|..|:||:..|
Worm   345 AFSIQNDVQYLFIHRVMLNYFL------------EKYKEK---YAALLTAENVAKYDKFIK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	71/251 (28%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
F36H12.10	NP_500756.1	PTPc	101..363	CDD:214550	81/286 (28%)
F36H12.10	NP_500756.1	PTPc	133..363	CDD:238006	73/254 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910