DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and ptpn-22

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_500128.2	Gene:	ptpn-22 / 176981	WormBaseID:	WBGene00021507	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	102/373 - (27%)
Similarity:	173/373 - (46%)	Gaps:	67/373 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DVEKQQRKS---------RAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNG-PID 84
            ::::|:.||         ..:...||.:.    ...|:.||       .|....:.|:||| |:.
Worm    17 EIQEQKPKSPPPPLPTSNPVVKDTPNVVP----TGDLIQFE-------SEEERAATTVPNGNPVI 70

  Fly    85 ----------IRHFLKLCD-------LRRKFPVLYKLE-FQTAAKVESNTCRHALKKNNLEKNQN 131
                      :|.|||..:       |||.:.:..:.| .:..|:..|. |  |:...:..:|:.
Worm    71 FEKNPAMDGLLREFLKEEEAYTPQDYLRRFYQIRVEQEKLRMEAEYRSE-C--AVAPQHYARNRY 132

  Fly   132 PKCIPYDYNRVVLEKVGGLQDSD----YVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQEN 192
            ...:|||.|||.::|     ||:    |:|||.:........:|..|.|:..|:..:|:|:.:..
Worm   133 RDILPYDKNRVEIQK-----DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHR 192

  Fly   193 ISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVT 257
            :|.:|:|.|..:..|:.|.:|||..:...|.:||..|.: .||:|.:......|..|| |.|...
Worm   193 VSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITL-EEEKLFDDDEYLMRCLKM-ENQTTG 255

  Fly   258 DERLILQFHYTEWYSHSCPFSNALLEFRRRVRLV--VGNI---IKDEDDMRGPILVHCSDGGGRS 317
            :.|.:.|.||.||..|.||...     ::.:.::  :.||   :..:|.  .|||||||.|.||:
Worm   256 ECRKVHQLHYREWPDHGCPSGE-----KQLLNMIDLMENIHEEVSPQDS--SPILVHCSAGVGRT 313

  Fly   318 GVYMSIDANLE--LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIY 363
            |..::|:...|  .||.....::||.:..||:.|..:|:..:|::|::
Worm   314 GTIIAINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVH 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	76/250 (30%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
ptpn-22	NP_500128.2	PTPc	102..365	CDD:214550	81/277 (29%)
ptpn-22	NP_500128.2	PTPc	129..365	CDD:238006	76/247 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910