DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp36E and moa-1

DIOPT Version :9

Sequence 1:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_497484.2	Gene:	moa-1 / 175340	WormBaseID:	WBGene00020116	Length:	1238	Species:	Caenorhabditis elegans

Alignment Length:	821	Identity:	157/821 - (19%)
Similarity:	281/821 - (34%)	Gaps:	250/821 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RAIVSIPNTIKLSMLNSGLLSFER------------IKLEARDENNSLSK---------TIPNGP 82
            :..|.....|||.:.:..:.:|:.            :||.|.|:...|||         |:.|
Worm   380 KPFVGAVTDIKLPVPSGNVPTFDNLDKFTKSTEELSLKLLAADKLVGLSKALHDSMNQHTLDN-- 442

  Fly    83 IDIRHFLKLCDLR-----RKFPVLYKLEFQTAAKVES--------------NTCRHALK------ 122
              :...:.:.|.:     :|....|||.|:....:.:              |..:| ||
Worm   443 --MSQIVNVTDAKFLESVQKINETYKLIFKEKGSMTTLSKGTILKDVTTVVNNFKH-LKAFVEKF 504

  Fly   123 ---KNNLE-KNQNPKCIPY-----DY-----NRV-----------VLEKVGGLQDSDYVNA---- 158
               |.:|| .|:..|..|.     ||     |:|           :.||:|.|  :.|:|.
Worm   505 KKFKKDLEFLNKIKKIEPVINFIKDYRGKTPNKVGLPILISSLPSIKEKLGNL--TAYINGIKSS 567

  Fly   159 --------SYVDSLLKPNAYI--VTQGPVEETVQAYWRMVWQ--ENISAIVMLTKTFDFAKVM-- 209
                    |...::.|.:..|  ||:|.......|..::.|:  :::||.:.:.|..:.|.|.
Worm   568 KDKETEALSVFTNIAKDSQVIGMVTRGITSMEEMASQKVDWKPLKDLSAAIKVMKKMNPADVKKL 632

  Fly   210 -----CHQYW---------------PPNMEVHEQYGDIF-----INIVREEQLANF-HIRTFRLY 248
                 ....|               |.|......|..||     :|.::....|.. .:.|.:..
Worm   633 EALAGLENEWKRIKGEVGTFINSVKPVNSTKLSDYSGIFQAAKSVNGLKTNLSAIISSVETLKSR 697

  Fly   249 KMNEKQEVTD-------ERLI-----LQFH----YTEWYSHSCPFSNALLE-FRRRVRLVVGNII 296
            ..:.::....       ::|:     ||.:    |:..:..|.....||:: |..     .|.|:
Worm   698 LPSRRKRAATGLTGAQLDKLLALLRPLQIYDPTIYSAAFDASAKSLQALVDSFTE-----YGKIL 757

  Fly   297 KDEDDMRGPILVHCSDGGG--RSGV----------------YMSIDANLELAEEEECFNVFGYLK 343
            ......:.|.   .|.||.  |.|.                |::|...:.||...  ..:|..|:
Worm   758 AKPPPPKPPA---PSPGGAAPRQGAAKPSSQNAPESISLWPYIAIGVIILLAIAG--LGIFFGLR 817

  Fly   344 --KLRQSRKGLVENVEQYKFIYDTLEEHI--ICGKTWFPVSELSDRLKAKARRNSGT--KMNEYQ 402
              ..:|.:..||.:....|.|...|.:.:  ||.:         ||..:..|||..|  .|..::
Worm   818 WWSKKQVKSDLVLDPAPTKTIIAILPDAVKYICDR---------DRRYSDFRRNESTFDFMKFFK 873

  Fly   403 AEYDQICKQTPRFTIGDCAGGHRADNR------EKNRDVLCVPPDNFRPYLTSFQGNAFTDYINS 461
            ..|:..........:.|....|..|.|      ||.|.:|       :.|...|..|    ::::
Worm   874 TSYENKVANMQSPEVSDLVKKHEMDLRVANPLIEKTRVIL-------KGYKKQFNDN----FLHA 927

  Fly   462 VFV---DGY-----------------TKPREYIVTEWPMKH-TLGEFWSLVYDQECSAVVVLCQP 505
            .:|   ||.                 .|.:|......|.:: |:.:||.::..::...||:.|..
Worm   928 NYVTCPDGMRFILMQSPQCEILEPKPAKEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDF 992

  Fly   506 PSQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFK-INKKIVSLTEMMAGVKAPTRT 569
            ..::::...|:.|.||           |...|..|.:   .|| |..|..::.: :.|::..|..
Worm   993 LERNRETGLFFENCSK-----------YYPMKVDTEL---TFKGITVKCTNMVK-VDGIERRTLC 1042

  Fly   570 VQL---FQLTCWPMGHKVPSSTNSL------VYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYC 625
            :..   .|||   :.|.:.||...|      :.:::::: :.||....|:.:...||.||:....
Worm  1043 ITFGDGVQLT---VTHNLMSSWTYLNTQKTTISIISLIQ-YLNKCKGAPIVIHDHDGISRSATIP 1103

  Fly   626 AANACIEQVIQ-HGEVDVFQAVKTVRRHRPQLVENMTEYKY 665
            |:....:::.: .|...:...:..:|.||...:....|..|
Worm  1104 ASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSY 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	65/345 (19%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	54/276 (20%)
moa-1	NP_497484.2	WSN	47..112	CDD:280385
		PTPc	868..1151	CDD:214550	59/307 (19%)
		PTPc	907..1149	CDD:304379	53/268 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000