Protein Alignment Ptp36E and ptprea

DIOPT Version :10

• Sequence 1: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_021336091.1
• Gene: ptprea / 100499203
• ZFINID: ZDB-GENE-100714-1
• Length: 711
• Species: Danio rerio
• Alignment Length: 666
• Identity: 192/666 - (28%)
• Similarity: 331/666 - (49%)
• Gaps: 87/666 - (13%)

  Fly    29 DDVEKQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKTIPNGPIDIRHFLKLCD 93
            ||:.....:.:.:|.:|                        .:.|.|||....|:|        :
Zfish   103 DDLGWPSEEQQTVVLLP------------------------RSPSTSKTYLPIPVD--------N 135

  Fly    94 LRRKFPV-------LYKLEFQT--AAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGG 149
            |..::.:       |::.|:.:  ...:: .||..|.|:.|.|||:.|..:|||.:||:|..:.|
Zfish   136 LEEEYRIRSADDGKLFREEYSSLPGGSIQ-GTCEEANKEENKEKNRYPNILPYDQSRVILTPMDG 199

  Fly   150 LQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYW 214
            :..|||:||||:|.....|.:|..|||.::|...:|||:|::..|.|||||...:..:..|:|||
Zfish   200 VTCSDYINASYIDGYKDKNKFIAAQGPKQDTTADFWRMIWEQKSSTIVMLTNLKERKEDKCYQYW 264

  Fly   215 PPNMEVHEQ----YGDIFINIVREEQLANFHIRTFRL-YKMNEKQEVTDERLILQFHYTEWYSHS 274
            |      :|    ||::.:.:.....|.::.||.|.: |:.::..:  ..||:.|.|:|.|....
Zfish   265 P------DQGCWTYGNVRVAVEDFTVLVDYTIRKFCVQYQASDGSK--SPRLVTQLHFTSWPDFG 321

  Fly   275 CPFSN-ALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNV 338
            .|||. .:|:|.::|:.|       .....|||:||||.|.||:|.::.|||.:::...|:..:|
Zfish   322 VPFSPIGMLKFLKKVKQV-------NPSYAGPIVVHCSAGVGRTGTFIVIDAMIDMMHTEQKVDV 379

  Fly   339 FGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQA 403
            ||::.::|:.|..|::...||.|:|..|.|:.:.|.|...||.|...|:.....|:.......:.
Zfish   380 FGFVSRIREQRSQLIQTDLQYSFVYQALLEYFLYGDTELDVSSLEGHLQKLHNTNAPLDRVGLEE 444

  Fly   404 EYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYT 468
            |:.::...  |....:...|:...|.:|||.:..:|.|..|..|:..:|..||||:|:.|:|||.
Zfish   445 EFKKLTNM--RIMKENMRTGNLPANMKKNRVLQIIPYDFNRVILSMKRGQEFTDYVNASFIDGYR 507

  Fly   469 KPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ----QYPSFWPNKSKMEKYGPVF 529
            :...||.|:.|:.||:.:||.:.::.:|.::|:|.:...:.|    ||   ||::..: .||. |
Zfish   508 QKDYYIATQGPLVHTVDDFWRMAWEWKCHSIVMLTELQERDQDKCFQY---WPSEDSV-TYGE-F 567

  Fly   530 SVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWP-MGHKVPSSTNSLVY 593
            ||..   |..|..:  .|.:...:::.|.     :..||.|:.|....|| :|  :|:....::.
Zfish   568 SVEI---KGDTLCE--TFSLRDLVLTHTP-----EKQTRLVRHFHFHGWPEIG--IPAEGKGMID 620

  Fly   594 LMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVE 658
            ::..|:..:.:....|:.|....|..|.|.:.|.:..:|:|...|.:||||.||::|..||.:|:
Zfish   621 IIAAVQKQQQQSGNHPIIVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQTVKSLRMQRPHMVQ 685

  Fly   659 NMTEYKYCYDLVLHYV 674
            .:.:|.:||.:|..:|
Zfish   686 TVEQYDFCYRVVQDFV 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	88/248 (35%)
		Y_phosphatase	428..671	CDD:459674	74/247 (30%)
ptprea	XP_021336091.1	R-PTPc-E-1	181..409	CDD:350468	84/242 (35%)
		PTP_DSP_cys	496..700	CDD:475123	64/220 (29%)