DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42750 and DPEP2

DIOPT Version :9

Sequence 1:	NP_724101.4	Gene:	CG42750 / 35090	FlyBaseID:	FBgn0261804	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_011521568.1	Gene:	DPEP2 / 64174	HGNCID:	23028	Length:	499	Species:	Homo sapiens

Alignment Length:	380	Identity:	184/380 - (48%)
Similarity:	240/380 - (63%)	Gaps:	30/380 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   688 SAPFEERLR-VAVQLLDQVPLIDGHNDLPWNIRKFLHNKLNDFNFDEDLRNVMPWGRSHWSHTDL 751
            |:|..:.|: .|..|:...||:|||||||..:|:.....|.|.|    |||.      .:..|.|
Human    65 SSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVN----LRNF------SYGQTSL 119

  Fly   752 TRLKKGRISAQFWAAYVPCEAQHRDAVQLTLEQIDVIKRLTDRYSPQLTTCTSAQDIIDAHKNQQ 816
            .||:.|.:.||||:|||||:.|.|||::|||||||:|:|:...|| :|...|||:.:.|   .|:
Human   120 DRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYS-ELELVTSAKALND---TQK 180

  Fly   817 LCSLTGVEGGHSLGGSLAVLRTLYAIGVRYMTLTSTCHTPWADSSYADAPTFNMKHGGLTIFGKT 881
            |..|.||||||||..||::|||.|.:||||:|||.||:||||:||.....:|.....|||.||:.
Human   181 LACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLTDFGEK 245

  Fly   882 IIREMNRLGMMVDLSHVSKGTMRDALEVSEAPVIFSHSSAYELCNTSRNVQDDILQALAKNGGLV 946
            ::.|||||||||||||||....|.|||||:||||||||:|..:||::|||.|||||.|.||||:|
Human   246 VVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDILQLLKKNGGVV 310

  Fly   947 MVNFYSKFLSCSDNSTVHDAVAHINHIKRVAGIDHVGLGAGYDGI-------------NYTPKGL 998
            ||:.....:.|:.::.|.....|.:|||.|.|...:|:|..|||.             :..|:||
Human   311 MVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKESGLKPTSWWPHRFPQGL 375

  Fly   999 EDVSSYPTLFAELLGGGWTIDELTKLAGGNFLRVMQQVEKLRDDKKAAGVKPFED 1053
            ||||:||.|..|||..||:.:||..:..||.|||.:||||::::.|  ...|.||
Human   376 EDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENK--WQSPLED 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42750	NP_724101.4	Peptidase_M19	701..1035	CDD:279569	172/346 (50%)
DPEP2	XP_011521568.1	Peptidase_M19	78..412	CDD:279569	172/347 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1182
eggNOG	1	0.900	-	-		E1_COG2355
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49703
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1272387at2759
OrthoFinder	1	1.000	-	-		FOG0001225
OrthoInspector	1	1.000	-	-		otm41951
orthoMCL	1	0.900	-	-		OOG6_102004
Panther	1	1.100	-	-	LDO	PTHR10443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7738
SonicParanoid	1	1.000	-	-		X677
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.810