DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and jmjd4

DIOPT Version :9

Sequence 1:	NP_001286031.1	Gene:	JMJD4 / 35089	FlyBaseID:	FBgn0032671	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001070096.1	Gene:	jmjd4 / 767690	ZFINID:	ZDB-GENE-060929-636	Length:	422	Species:	Danio rerio

Alignment Length:	430	Identity:	155/430 - (36%)
Similarity:	222/430 - (51%)	Gaps:	68/430 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QLPEEI--ERCSG---------LDYNDFFWRYMHKNIPVIIA-NVSNDWEC-QNWTVGQSSPESR 76
            :||.:|  :.||.         :.|:.||..|:..|.|.:.: ..:.:|.| :.|...:..|
Zfish    14 KLPRQIHQQHCSSHFIEYIEREIPYSKFFKNYLIPNQPCMFSKKFTEEWNCRKKWVTAEGKP--- 75

  Fly    77 DLNSNPSASSINFDYLKTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWT 141
                       |...|..:..:.|||||||:...:|::.|..:.|.:::..||.||:
Zfish    76 -----------NLQRLLHEFDETPVPVANCSVKEYNANPKQIMPFKEFIQYWRESIQ-------- 121

  Fly   142 SAEVNSNVAPASGDNLYLKDWHLAAQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKN 206
                |.:.:|..  .|||||||:....|.:|.||.|.||:||||||.......|||||||||||.
Zfish   122 ----NGHSSPKG--CLYLKDWHMQRNFPEHNIYKTPIYFSSDWLNEYWDTIEVDDYRFVYMGPKG 180

  Fly   207 SWTSYHADVFGSFSWSTNIVGLKKWLIMPPGEELKLNDRLGNLPFSIDEKMLD--------EHNV 263
            |||.:|||||.|:|||.||.|.||||:.|||:|..|.|..|||.:.:...:|.        |...
Zfish   181 SWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDFLRDCHGNLAYDVTAPILQDKGLYAQFEEAC 245

  Fly   264 RYYTINQRANEAVFVPSGWFHQVWNLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQQ 328
            :...|.|.|.|.:||||||.|||:||.||||:||||.||||:.::||.|::.|.:|..||.:.:.
Zfish   246 QPLEIIQEAGEIIFVPSGWHHQVYNLEDTISINHNWLNGCNLDIMWQFLQDELSSVQREIEEWRD 310

  Fly   329 -MDNFEAHCQTMLRASFGINYLDFIELLEFIAARRLA------EGTVATKFLLFDSY-TMNDYHV 385
             ||.:..|||.::::..||:|.:|...|:.||..|::      ....:.:.||.:|. .:..:|.
Zfish   311 TMDTWHQHCQVIMKSCTGIDYAEFASFLKTIANNRISFLNSSPRNADSCQDLLAESLCALGPHHA 375

  Fly   386 QYDLECLWKITRTLTE-------DP-TIQCSPLQLEDRCQ 417
            .:||:.:..|...:..       || |:...|   ||..|
Zfish   376 AFDLQRVLHIFEIMLNNEDFKRLDPATLSFKP---EDLLQ 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_001286031.1	JmjC	172..221	CDD:214721	32/48 (67%)
JMJD4	NP_001286031.1	JmjC	199..299	CDD:202224	58/107 (54%)
jmjd4	NP_001070096.1	cupin_like	38..281	CDD:304367	110/270 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578631
Domainoid	1	1.000	89	1.000	Domainoid score	I7863
eggNOG	1	0.900	-	-		E1_KOG2131
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11306
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3078
OMA	1	1.010	-	-		QHG60265
OrthoDB	1	1.010	-	-		D369628at33208
OrthoFinder	1	1.000	-	-		FOG0006315
OrthoInspector	1	1.000	-	-		oto39879
orthoMCL	1	0.900	-	-		OOG6_104551
Panther	1	1.100	-	-	LDO	PTHR12480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R627
SonicParanoid	1	1.000	-	-		X4599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800