DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and JMJD4

DIOPT Version :9

Sequence 1:	NP_001286031.1	Gene:	JMJD4 / 35089	FlyBaseID:	FBgn0032671	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_075383.3	Gene:	JMJD4 / 65094	HGNCID:	25724	Length:	417	Species:	Homo sapiens

Alignment Length:	380	Identity:	137/380 - (36%)
Similarity:	196/380 - (51%)	Gaps:	42/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 YNDFFWRYMHKNIPVIIANV-SNDW-ECQNWTVGQSSPESRDLNSNPSASSINFDYLKTKISDGP 100
            |.||...::..|:|.:.::. :..| ..:.|......|:              ||:|.....|..
Human    41 YADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPD--------------FDHLLRTYGDVV 91

  Fly   101 VPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNLYLKDWHLA 165
            ||||||....:||:.|..:...||:..|:..|:    |.::|..          ..||||||||.
Human    92 VPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQ----AGYSSPR----------GCLYLKDWHLC 142

  Fly   166 AQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSFSWSTNIVGLKK 230
            ...|..:.:.:|.||:||||||.......|||||||.||..||:.:|||:|.|||||.|:.|.||
Human   143 RDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKK 207

  Fly   231 WLIMPPGEELKLNDRLGNLPFSIDEKMLDEHNVR--------YYTINQRANEAVFVPSGWFHQVW 287
            ||:.|||:|..|.||.||||:.:....|.:.::.        ...|.|.|.|.|||||||.|||.
Human   208 WLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVH 272

  Fly   288 NLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQ-QMDNFEAHCQTMLRASFGINYLDF 351
            ||.||||:||||.||.|::.:|:.|:..|.||..|:|:.: .|.::..|||.::|:..|||:.:|
Human   273 NLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEF 337

  Fly   352 IELLEFIAARRLAEGTVATKFLLFDSYTMNDYHVQYDLECLWKITRTLTEDPTIQ 406
            ...|:.||.:||   .|..:....|...:......:|:..:.::..:|...|..|
Human   338 YHFLKVIAEKRL---LVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_001286031.1	JmjC	172..221	CDD:214721	26/48 (54%)
JMJD4	NP_001286031.1	JmjC	199..299	CDD:202224	56/107 (52%)
JMJD4	NP_075383.3	cupin_RmlC-like	42..288	CDD:424065	93/255 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145370
Domainoid	1	1.000	123	1.000	Domainoid score	I5626
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11306
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3339
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60265
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006315
OrthoInspector	1	1.000	-	-		oto90654
orthoMCL	1	0.900	-	-		OOG6_104551
Panther	1	1.100	-	-	LDO	PTHR12480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R627
SonicParanoid	1	1.000	-	-		X4599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930