Protein Alignment JMJD4 and JMJD4

DIOPT Version :10

• Sequence 1: NP_609870.1
• Gene: JMJD4 / 35089
• FlyBaseID: FBgn0032671
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_075383.3
• Gene: JMJD4 / 65094
• HGNCID: 25724
• Length: 417
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 137/380 - (36%)
• Similarity: 196/380 - (51%)
• Gaps: 42/380 - (11%)

  Fly    38 YNDFFWRYMHKNIPVIIANV-SNDW-ECQNWTVGQSSPESRDLNSNPSASSINFDYLKTKISDGP 100
            |.||...::..|:|.:.::. :..| ..:.|......|:              ||:|.....|..
Human    41 YADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPD--------------FDHLLRTYGDVV 91

  Fly   101 VPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNLYLKDWHLA 165
            ||||||....:||:.|..:...||:..|:..|:    |.::|..          ..||||||||.
Human    92 VPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQ----AGYSSPR----------GCLYLKDWHLC 142

  Fly   166 AQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSFSWSTNIVGLKK 230
            ...|..:.:.:|.||:||||||.......|||||||.||..||:.:|||:|.|||||.|:.|.||
Human   143 RDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKK 207

  Fly   231 WLIMPPGEELKLNDRLGNLPFSIDEKMLDEHNVR--------YYTINQRANEAVFVPSGWFHQVW 287
            ||:.|||:|..|.||.||||:.:....|.:.::.        ...|.|.|.|.|||||||.|||.
Human   208 WLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVH 272

  Fly   288 NLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQ-QMDNFEAHCQTMLRASFGINYLDF 351
            ||.||||:||||.||.|::.:|:.|:..|.||..|:|:.: .|.::..|||.::|:..|||:.:|
Human   273 NLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEF 337

  Fly   352 IELLEFIAARRLAEGTVATKFLLFDSYTMNDYHVQYDLECLWKITRTLTEDPTIQ 406
            ...|:.||.:||   .|..:....|...:......:|:..:.::..:|...|..|
Human   338 YHFLKVIAEKRL---LVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQ 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_609870.1	Cupin_8	39..299	CDD:463936	104/269 (39%)
		JmjC	199..299	CDD:396791	56/107 (52%)
JMJD4	NP_075383.3	Cupin_8	42..284	CDD:463936	90/251 (36%)
		cupin_RmlC-like	176..284	CDD:477354	55/115 (48%)