DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and Jmjd4

DIOPT Version :9

Sequence 1:	NP_001286031.1	Gene:	JMJD4 / 35089	FlyBaseID:	FBgn0032671	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001099254.1	Gene:	Jmjd4 / 287359	RGDID:	1307186	Length:	426	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	135/350 - (38%)
Similarity:	188/350 - (53%)	Gaps:	46/350 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IERCSGLDYNDFFWRYMHKNIPVIIANV-SNDW-ECQNWTVGQSSPESRDLNSNPSASSINFDYL 92
            |:......|.||...::..|:|.:.::. :..| ..:.|...:..|:              |:||
  Rat    34 IQAPDAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPD--------------FEYL 84

  Fly    93 KTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNL 157
            ..|..|..||||||....:||:.|..:.|.||::.|:..|:...|            :|..  .|
  Rat    85 LQKYGDAVVPVANCGVREYNSNPKEHMPFRDYISYWKEYIQGGYS------------SPRG--CL 135

  Fly   158 YLKDWHLAAQM---PGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSF 219
            |||||||....   ...:.:.:|.||:||||||.......|||||||.|||.:|:.:|||:|.||
  Rat   136 YLKDWHLCRDSLVDDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPKGTWSPFHADIFRSF 200

  Fly   220 SWSTNIVGLKKWLIMPPGEELKLNDRLGNLPFSI-DEKMLDEHNVRYYTIN---------QRANE 274
            |||.||.|.||||..|||:|..|.|..||||:.: ..::||.|  .|..|.         |...|
  Rat   201 SWSVNICGKKKWLFFPPGQEEALRDCRGNLPYDVTSTELLDTH--LYPRIQQDSLPIEVIQEPGE 263

  Fly   275 AVFVPSGWFHQVWNLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQ-QMDNFEAHCQT 338
            .|||||||.|||:||.||||:||||.||||::.:|..|:..|:||.:|:.:.: .|.::..|||.
  Rat   264 MVFVPSGWHHQVYNLEDTISINHNWVNGCNLANMWHFLQQELQAVQHEVGEWKDSMPDWHHHCQV 328

  Fly   339 MLRASFGINYLDFIELLEFIAARRL 363
            ::::..||||.:|...|:.||.:||
  Rat   329 IMKSCTGINYEEFYHFLKVIAEKRL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_001286031.1	JmjC	172..221	CDD:214721	26/48 (54%)
JMJD4	NP_001286031.1	JmjC	199..299	CDD:202224	58/109 (53%)
Jmjd4	NP_001099254.1	cupin_like	49..288	CDD:304367	105/268 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339047
Domainoid	1	1.000	121	1.000	Domainoid score	I5571
eggNOG	1	0.900	-	-		E1_KOG2131
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11306
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3224
OMA	1	1.010	-	-		QHG60265
OrthoDB	1	1.010	-	-		D369628at33208
OrthoFinder	1	1.000	-	-		FOG0006315
OrthoInspector	1	1.000	-	-		oto97763
orthoMCL	1	0.900	-	-		OOG6_104551
Panther	1	1.100	-	-	LDO	PTHR12480
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770