DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and jmjd6

DIOPT Version :9

Sequence 1:	NP_001286031.1	Gene:	JMJD4 / 35089	FlyBaseID:	FBgn0032671	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_739567.3	Gene:	jmjd6 / 266962	ZFINID:	ZDB-GENE-040426-17	Length:	403	Species:	Danio rerio

Alignment Length:	313	Identity:	77/313 - (24%)
Similarity:	117/313 - (37%)	Gaps:	89/313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EEIERC--SGLDYNDFFWRYMHKNIPVIIANVSNDWEC-QNWTVGQ----------SSPESRDLN 79
            :.:||.  ..|...:|..|:.....||::.||.:.|.. :.||:.:          ...|..|..
Zfish    44 DNVERADVQRLSPEEFIQRFEKPYKPVVLLNVEDSWPAREKWTLERLKRKYRNQKFKCGEDNDGY 108

  Fly    80 SNPSASSINFDYLKTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAE 144
            |.........:||::...|.|:.:.:   |.|..|           ||.|..:|.
Zfish   109 SVKMKMKYYVEYLESTHDDSPLYIFD---SSFGEH-----------AKRRKLLED---------- 149

  Fly   145 VNSNVAPASGDNLYLKDWHLAAQMPGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWT 209
                                         |:||.:|..| |.:...::.:..||:..|||..|.|
Zfish   150 -----------------------------YQVPLFFRDD-LFQFAGEKRRPPYRWFVMGPARSGT 184

  Fly   210 SYHADVFGSFSWSTNIVGLKKWLIMP---PGEELKL-NDRLGNLPFSIDEKMLDEHNVRY----- 265
            ..|.|..|:.:|:..:.|.|:|.:.|   |.|.:|: .|..||.    .::.:...||.|
Zfish   185 GIHIDPLGTSAWNALVQGHKRWCLFPTHTPRELIKVTRDEGGNQ----QDEAITWFNVIYPRTQQ 245

  Fly   266 ---------YTINQRANEAVFVPSGWFHQVWNLTDTISVNHNWFNGCNISMVW 309
                     ..|.||..|.||||.||:|.|.||..||:|..|:.:..|..:||
Zfish   246 STWPDEFRPLEILQRPGETVFVPGGWWHVVLNLDTTIAVTQNFASTTNFPIVW 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_001286031.1	JmjC	172..221	CDD:214721	16/48 (33%)
JMJD4	NP_001286031.1	JmjC	199..299	CDD:202224	39/117 (33%)
jmjd6	NP_739567.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Nuclear localization signal 1. /evidence=ECO:0000250\|UniProtKB:Q6NYC1	6..10
		Nuclear localization signal 2. /evidence=ECO:0000250\|UniProtKB:Q6NYC1	91..95		0/3 (0%)
		Nuclear localization signal 3. /evidence=ECO:0000250\|UniProtKB:Q6NYC1	141..145		2/3 (67%)
		Nuclear localization signal 4. /evidence=ECO:0000250\|UniProtKB:Q6NYC1	167..170		0/2 (0%)
		JmjC	174..288	CDD:202224	39/117 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..403
		Nuclear localization signal 5. /evidence=ECO:0000250\|UniProtKB:Q6NYC1	373..378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369628at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920