DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and Jmjd4

DIOPT Version :9

Sequence 1:	NP_001286031.1	Gene:	JMJD4 / 35089	FlyBaseID:	FBgn0032671	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_848774.1	Gene:	Jmjd4 / 194952	MGIID:	2144404	Length:	427	Species:	Mus musculus

Alignment Length:	414	Identity:	147/414 - (35%)
Similarity:	218/414 - (52%)	Gaps:	58/414 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IERCSGLDYNDFFWRYMHKNIPVIIANV-SNDW-ECQNWTVGQSSPESRDLNSNPSASSINFDYL 92
            |:..:...|.||...::..|:|.:.::. :..| ..:.|...:..|:              |:||
Mouse    35 IQTPNAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPD--------------FEYL 85

  Fly    93 KTKISDGPVPVANCNSSYFNSHTKLELNFHDYLAKWRSSIESQSSAAWTSAEVNSNVAPASGDNL 157
            :.|..|..||||||....:||:.|..::|.||::.|:..|:...|              :|...|
Mouse    86 QQKYGDAVVPVANCGVREYNSNPKEHMSFRDYISYWKDYIQGSYS--------------SSRGCL 136

  Fly   158 YLKDWHLAAQM---PGYNFYKVPKYFASDWLNEQLIQQGKDDYRFVYMGPKNSWTSYHADVFGSF 219
            |||||||....   ...:.:.:|.||:||||||.......|||||||.||:.:|:.:|||:|.||
Mouse   137 YLKDWHLCRDSLVNDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHADIFRSF 201

  Fly   220 SWSTNIVGLKKWLIMPPGEELKLNDRLGNLPFSI-DEKMLDEH---NVRYYT----INQRANEAV 276
            |||.||.|.||||..|||||..|.|..||||:.: ..::||.|   .:::::    :.|...|.|
Mouse   202 SWSVNICGKKKWLFFPPGEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQEPGEMV 266

  Fly   277 FVPSGWFHQVWNLTDTISVNHNWFNGCNISMVWQNLKNNLKAVCNEISDCQ-QMDNFEAHCQTML 340
            ||||||.|||:||.||||:||||.||||:..:|..|:..|:||.:|:.:.: .|.::..|||.::
Mouse   267 FVPSGWHHQVYNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSMPDWHHHCQVIM 331

  Fly   341 RASFGINYLDFIELLEFIAARRLAEGTVATKFLLFDSYTMNDYHVQ---YDLECLWKITRTLTED 402
            ::..|||:.:|...|:.||.:||.......|....||.:: |..:|   :|:..|..:..::..:
Mouse   332 KSCTGINFEEFYHFLKVIAEKRLLVLEQGLKGDSGDSRSL-DLGLQQAAFDIGRLADVLASVVVN 395

  Fly   403 PTIQ------CSP------LQLED 414
            |..|      .||      .||||
Mouse   396 PDFQRVDTSAFSPQPEELLQQLED 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_001286031.1	JmjC	172..221	CDD:214721	25/48 (52%)
JMJD4	NP_001286031.1	JmjC	199..299	CDD:202224	56/107 (52%)
Jmjd4	NP_848774.1	cupin_like	38..289	CDD:304367	106/278 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835430
Domainoid	1	1.000	80	1.000	Domainoid score	I8617
eggNOG	1	0.900	-	-		E1_KOG2131
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11306
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3242
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60265
OrthoDB	1	1.010	-	-		D369628at33208
OrthoFinder	1	1.000	-	-		FOG0006315
OrthoInspector	1	1.000	-	-		oto94242
orthoMCL	1	0.900	-	-		OOG6_104551
Panther	1	1.100	-	-	LDO	PTHR12480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R627
SonicParanoid	1	1.000	-	-		X4599
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800