DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5783 and TSC1

DIOPT Version :9

Sequence 1:	NP_609869.1	Gene:	CG5783 / 35088	FlyBaseID:	FBgn0032670	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_000359.1	Gene:	TSC1 / 7248	HGNCID:	12362	Length:	1164	Species:	Homo sapiens

Alignment Length:	123	Identity:	34/123 - (27%)
Similarity:	52/123 - (42%)	Gaps:	27/123 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AKQARDEGLFVIVDRYQL---------FVGCLNNTNG--LVGKALDLLDWSSGLKCSSIPSRHIG 110
            |:||....|..::|...|         |...||:..|  ||...:|..     |:.||.|:.||
Human     2 AQQANVGELLAMLDSPMLGVRDDVTAVFKENLNSDRGPMLVNTLVDYY-----LETSSQPALHI- 60

  Fly   111 ALDSLVESKKLNLVYRDCTNLFFMKANDALKLKVEPPSGFVLK-----SLSVADAPLV 163
             |.:|.|....:|:  |..|.:..||  |.:|.:....|.|::     ...::.|||:
Human    61 -LTTLQEPHDKHLL--DRINEYVGKA--ATRLSILSLLGHVIRLQPSWKHKLSQAPLL 113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5783	NP_609869.1	Gly_acyl_tr_N	<91..183	CDD:283638	22/78 (28%)
CG5783	NP_609869.1	FR47	187..272	CDD:117022
TSC1	NP_000359.1	Hamartin	7..719	CDD:398199	31/118 (26%)
		Mediates interaction with WDR45B. /evidence=ECO:0000269\|PubMed:28561066	403..787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..571
		Smc	<751..>971	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1006..1085
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1131..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S1135
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950