DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs36E and SOCS5

DIOPT Version :9

Sequence 1:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_054730.1	Gene:	SOCS5 / 9655	HGNCID:	16852	Length:	536	Species:	Homo sapiens

Alignment Length:	530	Identity:	176/530 - (33%)
Similarity:	248/530 - (46%)	Gaps:	103/530 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 SSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNANCPLE---------ADDDDDLDESLL 203
            |:|:   .:..|:..| :|..:|.:.|    .::...|.||..|         ..|:|.......
Human    50 STPQ---QQSSPLREN-IALQLGLSPS----KNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGT 106

  Fly   204 RRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNS 268
            |..|.:|.||        |.....:::|..                  |..||.|.....:...:
Human   107 RLARRDSYSR--------HAPWGGKKKHSC------------------STKTQSSLDADKKFGRT 145

  Fly   269 NSCCRSRSSKALSMGAATSSASGSASTSVSTSTSSKRRCCKCKCRDAIRGL----RDMLPSSSSS 329
            .|..:.|..:   .|.::.....|.|:....|.|.::|     .:|.: ||    |.....|...
Human   146 RSGLQRRERR---YGVSSVHDMDSVSSRTVGSRSLRQR-----LQDTV-GLCFPMRTYSKQSKPL 201

  Fly   330 VSNKK------------------DAAAVVAMVPRKSRTADRRST-----PPTLGTSSGGSQRRMQ 371
            .|||:                  |.|....::.:.:......||     .|:|.::.....|..:
Human   202 FSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRE 266

  Fly   372 SQRIRNSVAV---PDASHHHHQLIIRIT---------SPGFVVESPNGGRVTVVTEPAPQSPQT- 423
            .:|:.....|   |:|..|..:...::.         :||....|.:...:......:.:...|
Human   267 RRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTL 331

  Fly   424 -----PPRPRPLATVAPAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKMDRYE 483
                 ..:.|.::      |..|..:.......||:|||::|||||||.:||.:..|||.|||||
Human   332 CLQSRRQKQRQIS------GDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYE 390

  Fly   484 AEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGL 548
            ||.||||||||||||||||||::||||:||:|.|||||||||..|.||||.||||||.:.|||||
Human   391 AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGL 455

  Fly   549 LEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHYK 613
            |||||||:..|||||.|||.|:|...||||.:.||.|...|:||||:.:.||..|:.:|||||||
Human   456 LEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520

  Fly   614 QKLRVKPIDQ 623
            ||:||:.:::
Human   521 QKVRVRWLER 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	76/99 (77%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	26/49 (53%)
SOCS5	NP_054730.1	Required for interaction with IL4R. /evidence=ECO:0000250	1..50		176/530 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..175		13/88 (15%)
		SOCS	146..195	CDD:403716	12/57 (21%)
		SH2	370..470	CDD:417686	76/99 (77%)
		SOCS_SOCS5	479..534	CDD:239708	26/52 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142957
Domainoid	1	1.000	97	1.000	Domainoid score	I7282
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002657
OrthoInspector	1	1.000	-	-		otm41980
orthoMCL	1	0.900	-	-		OOG6_109258
Panther	1	1.100	-	-	LDO	PTHR10155
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2417
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.700