Protein Alignment Socs36E and SOCS1

DIOPT Version :9

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_003736.1
• Gene: SOCS1 / 8651
• HGNCID: 19383
• Length: 211
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 64/228 - (28%)
• Similarity: 92/228 - (40%)
• Gaps: 54/228 - (23%)

  Fly   410 VTVVTEP---------APQSPQTPPRPRPLATV-APAGGAGHAGIGAARNMTVHSQIDFMHCLVP 464
            |:...||         :..||..|.||||...| |||.|..|     .|....|:
Human    13 VSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTH-----FRTFRSHA---------- 62

  Fly   465 DLEKITNSS-------FYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHAR 522
            |..:||.:|       ||||.:..:.|...|..:|.||||:|||.|....|:::.:........|
Human    63 DYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIR 127

  Fly   523 IEQSGHKF-------SFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQL 580
            :.....:|       ||||          :..|||||     |......|..||.:|:...||:|
Human   128 VHFQAGRFHLDGSRESFDC----------LFELLEHY-----VAAPRRMLGAPLRQRRVRPLQEL 177

  Fly   581 SRATIVSNTSYDGINQMELPGRLKSYLKEYHYK 613
            .|..||:....:.:.::.|...|:.||..:.::
Human   178 CRQRIVATVGRENLARIPLNPVLRDYLSSFPFQ 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	32/113 (28%)
		SOCS	575..626	CDD:295349	10/39 (26%)
SOCS1	NP_003736.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		15/39 (38%)
		Kinase inhibitory region (KIR)	55..66		3/20 (15%)
		Extended SH2 subdomain (ESS)	67..78		3/10 (30%)
		SH2_SOCS1	68..165	CDD:198245	31/111 (28%)
		SOCS_SOCS1	169..211	CDD:239704	11/42 (26%)
		Interaction with Elongin BC complex. /evidence=ECO:0000250	173..182		4/8 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740