DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Socs36E and TNP2

DIOPT Version :9

Sequence 1:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_005416.1	Gene:	TNP2 / 7142	HGNCID:	11952	Length:	138	Species:	Homo sapiens

Alignment Length:	141	Identity:	34/141 - (24%)
Similarity:	57/141 - (40%)	Gaps:	40/141 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 SLPVSN-MLSAGTQHSSKPVSR--SNNSNSCCRS-RSSKALSMGAATS---------SASGSAST 295
            |||::: .|.:.:|..|:..:|  ...|.||.:| |.|::.|...:.:         |:||..|.
Human     7 SLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPTGAHSSSGHQSQ 71

  Fly   296 SVSTSTSSKRR----------------CCKC-KCRDAIRGLRDMLPSSSSSVSNKKDAAAVVAMV 343
            |.:||...||.                .|:| |.|..:.|          .:..||.|..:..:.
Human    72 SPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEG----------KLKKKKMAKRIQQVY 126

  Fly   344 PRKSRTADRRS 354
            ..|:|::..:|
Human   127 KTKTRSSGWKS 137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349
TNP2	NP_005416.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..138		34/141 (24%)
		TP2	1..134	CDD:279579	33/136 (24%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P11101	111..119		3/17 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900