Protein Alignment Socs36E and Socs5

DIOPT Version :10

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_062628.2
• Gene: Socs5 / 56468
• MGIID: 2385459
• Length: 536
• Species: Mus musculus
• Alignment Length: 561
• Identity: 186/561 - (33%)
• Similarity: 250/561 - (44%)
• Gaps: 121/561 - (21%)

  Fly   132 EGGYGEVGV---------VTNRTAGSSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNAN 187
            |||.....|         |..::......|.:.|..|:..| :|..:|.:.|......|....|.
Mouse    22 EGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLREN-VALQLGLSPSKTFSRRNQNCAAE 85

  Fly   188 CP------LEADDDDDLDESLLRRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLP 246
            .|      :|.|.|...... .|..|.:|.||        |.....:::|..
Mouse    86 IPQVVEISIEKDSDSGATPG-TRLARRDSYSR--------HAPWGGKKKHSC------------- 128

  Fly   247 VSNMLSAGTQHSSKPVSRSNNSNSCCRSRS-----SKALSMGAATSSASGSASTSVSTSTSSKRR 306
                 |..||.|.....:...:.|..:.|.     |....|.:.:|.|.||             |
Mouse   129 -----STKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGS-------------R 175

  Fly   307 CCKCKCRDAIRGL----RDMLPSSSSSVSNKK------------------DAAAVVAMVPRKSRT 349
            ..:.:.:|.: ||    |.....|....|||:                  |.|....::.:.:..
Mouse   176 SLRQRLQDTV-GLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAP 239

  Fly   350 ADRRST-----PPTLGTSSGGSQRRMQSQRIRNSVAV---PDASHHHHQLIIRIT---------S 397
            ....||     .|:|.::.....|..:.:|:.....|   |:|..|..:...::.         :
Mouse   240 VSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLA 304

  Fly   398 PGFVVESPNGGRVTVVTEPAPQSPQTPPRPRPLATV----------APAGGAGHAGIGAARNMTV 452
            ||....|.:|..:          |||.......:|.          ....|..||.:.......|
Mouse   305 PGMTEISGDGSAI----------PQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKV 359

  Fly   453 HSQIDFMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGR 517
            |:|||::|||||||.:||.:..|||.|||||||.||||||||||||||||||::||||:||:|.|
Mouse   360 HTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNR 424

  Fly   518 SLHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSR 582
            ||||||||..|.||||.||||||.:.||||||||||||:..|||||.|||.|:|...||||.:.|
Mouse   425 SLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICR 489

  Fly   583 ATIVSNTSYDGINQMELPGRLKSYLKEYHYKQKLRVKPIDQ 623
            |.|...|:||||:.:.||..|:.:|||||||||:||:.:::
Mouse   490 AVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLER 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:472789	76/99 (77%)
		SOCS	575..626	CDD:470605	26/49 (53%)
Socs5	NP_062628.2	Required for interaction with IL4R	1..50		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..59		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..175		22/119 (18%)
		SOCS	145..195	CDD:432667	13/63 (21%)
		SH2	370..470	CDD:472789	76/99 (77%)
		SOCS_SOCS5	479..534	CDD:239708	26/52 (50%)