DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs36E and socs7

DIOPT Version :9

Sequence 1:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	XP_009304138.1	Gene:	socs7 / 556903	ZFINID:	ZDB-GENE-080204-125	Length:	777	Species:	Danio rerio

Alignment Length:	712	Identity:	157/712 - (22%)
Similarity:	234/712 - (32%)	Gaps:	229/712 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 ADGATDDDAAALSA-----------DSLNANGQIVNVTLEGGYGEVGVV----TNRTAGSSPEAA 153
            |.|....||..::.           .|..|:|  .::|..||.|...:|    :..:.|.|...:
Zfish    64 ASGTEAPDAGVMATRPALSVPPPPLHSAEAHG--YDLTHRGGMGPQLLVFRNISRDSEGFSENKS 126

  Fly   154 KTERQPVNNNGLAGSVGAAIS-----TLQLHDNHGGNANCPLEADDDDDLDESLLRRRR--SNSN 211
            :.:|:...:..|..|...|:.     |..||.    ....|..|.|.|  ...|..|.|  ::..
Zfish   127 EDQRRAFEDQALLASESGAVDAQHPPTWTLHP----QLKLPAVATDTD--GGELCHRHRLITDQQ 185

  Fly   212 SRSNIHHHHHHHQ--QQQQQQHEAEVVEYCEVLESL---PVSNML----------------SAGT 255
            ....:..|.....  |:|.|..|..|:|.......|   ||...|                |||.
Zfish   186 DWPPVVEHKTSSMTVQRQLQLPEGPVLELARKFGELGVAPVPEFLLKDGELQHCSCQSVLGSAGM 250

  Fly   256 QHSSKPVSRSN----------------NSNSCCRSRSSK----ALSMGAATSSASGSASTSVSTS 300
            :....|...|:                ..|:|.:..|..    |.::....|..||.| ..||..
Zfish   251 RQGEDPTETSDALLVLEGLGSEEVNGLGINACQKPESQTTEPGAFALKCFPSVLSGQA-MGVSGG 314

  Fly   301 TSSKRRCCKCKCRDAIRGLRDMLPSSSSSVSNKKDAAAVVAMVP---------RKSRTADRRSTP 356
            ..|. .||.         |||       ||:|:..|.|...::|         :::..:.:.|||
Zfish   315 LCSP-TCCL---------LRD-------SVNNRPQAPAADKLIPEVISQAEPSQETPCSSQASTP 362

  Fly   357 PT-------LGTSSGG-------SQRRMQSQRIRNS--VAVPDASHHHHQLIIR------ITSPG 399
            ..       |..:|||       .:.|..|.:||.|  ......|..::.|..|      |:|.|
Zfish   363 KARSSSRAHLSAASGGEKTLKVPGKSRKGSLKIRLSKLFRTKSCSGSNNLLDKRPSVTFSISSAG 427

  Fly   400 FVVE-----------------------------SP--NGGRVTVV---------TEPAPQSPQTP 424
            .:|:                             :|  .|..|::|         ..|.|.:|..|
Zfish   428 SLVDMSGAIGGEQDTSSQPGLTRAQSAFSAASFTPVFTGETVSLVDVDISQRGRNSPHPPTPPPP 492

  Fly   425 PR-----------PRPLATVAPAGGAG--------------HAGIGAARNMT-------VHSQID 457
            ||           |:|...:....||.              ||.|..:.::.       .||...
Zfish   493 PRRSLSLLDDIGGPQPGPFLVSVMGASLQSLPLPLPPPPPLHATIQHSLSLNDAFFRALPHSAAS 557

  Fly   458 FMHCLVP----------------------DLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRD 500
            .|....|                      .|.::....:|||.|:..:||..|.|||:|:||:||
Zfish   558 PMENPAPARLAPPQVMCPLRGADSSSFTASLRELERCGWYWGPMNWEDAEMKLRGKPDGSFLVRD 622

  Fly   501 SAQEEFLFSVTFRKYGRSLHARIEQSGHKFSFDCH----DPCVFTAPTVTGLLEHYKDPACVMFF 561
            |:...::.|::||..|.:.|.|:|.....||..||    |.|......:...:.|.|:...:.|.
Zfish   623 SSDPRYILSLSFRSQGVTHHTRMEHYRGTFSLWCHPKFEDRCHSVVEFIERAIMHSKNGKFLYFL 687

  Fly   562 E---------PC-LTIPLHR-RQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHY 612
            .         |. |..|:.| ....|||.|.|..|......|.|.::.||..|..||::::|
Zfish   688 RSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFCIRQLVRIDHIQELPLPKPLIVYLRKFYY 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	34/134 (25%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	14/38 (37%)
socs7	XP_009304138.1	SH2_SOCS7	585..685	CDD:198251	32/99 (32%)
socs7	XP_009304138.1	SOCS_SOCS7	709..757	CDD:239710	14/41 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810