DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs36E and socs5

DIOPT Version :9

Sequence 1:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001016844.1	Gene:	socs5 / 549598	XenbaseID:	XB-GENE-479593	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	189/583 - (32%)
Similarity:	269/583 - (46%)	Gaps:	143/583 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DDDAAALSADSLNANGQIVNVTL-EGGYGEVGVVT------NRTAGSSPEAAKTER--------- 157
            ||:|.......:|||..:..:.. |...|:..:::      |.|:..||.::.:.|
Frog    22 DDEANQNDTVDVNANRCLGGIDKNENASGQSAMLSIGPLQQNITSELSPSSSSSRRNQNCVSEMP 86

  Fly   158 -------QPVNNNGLAGSVGAAISTLQLHDNH---GGNA--NCPLEADDDDDLDESLLRRRRSNS 210
                   :..|::||  |.|..::....:..|   ||..  :|..:..:..|.|:.:.|
Frog    87 QLVEISVERDNDSGL--SAGTRLARRDSYTRHAPWGGKKKHSCSTKTQNSFDPDKKICR------ 143

  Fly   211 NSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNSNSCC--- 272
             :||.:        |:::::|.|..|...|.:.|..|.         |.....|.|.:...|
Frog   144 -TRSGL--------QRRERRHGANSVHDMETIGSRAVG---------SRSLRQRLNETVGLCFPI 190

  Fly   273 --RSRSSKALSMGAATSSASGSASTSVSTSTSSKRRCC-------KCKCRDAIRGLRDMLPSSSS 328
              .:|.||.|                    .::||:..       ||.           .|..|.
Frog   191 RTYNRPSKPL--------------------FTNKRKIHLSELMLEKCP-----------FPPGSD 224

  Fly   329 SVSN----KKDAAAVVAMVPRKS--RTADRRSTPPTLGTSSGGSQRRMQSQR---IRNSV-AVPD 383
            ....    |:..|.|   .|..|  .|.|:..      .|:...:.|::.:|   |...| ..|:
Frog   225 LAQKWHLIKQHTAPV---SPHSSFLETFDQSV------VSAEDEEDRLRERRRLSIEEGVDPPPN 280

  Fly   384 ASHHHHQLIIRIT---------SPGFVVESPNGGRVTVVTEPAPQSPQTP---------PRPRPL 430
            |..|..:...::.         :||....|   |.|..|.:...:|.:..         .:.|..
Frog   281 AQIHTFEATAQVNPVYKLGPKLAPGMADIS---GDVNAVCQGGCESEEDTTTLCLQSRRQKQRQF 342

  Fly   431 ATVAPAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGT 495
            :      |..|..|.......||:|||::|||||||.:|.::..|||.|||||||.||||:||||
Frog   343 S------GDSHTQITKQGAWKVHTQIDYIHCLVPDLIEIISNPCYWGVMDRYEAEALLEGRPEGT 401

  Fly   496 FLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEHYKDPACVMF 560
            |||||||||::||||:||:|.|||||||||..|.||||.||||||.:.||||||||||||:..||
Frog   402 FLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMF 466

  Fly   561 FEPCLTIPLHRRQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHYKQKLRVKPIDQ 623
            |||.||:||:|...||||.:.||.|..:|:||||:.:.||..|:.:|||||||||:||:.:::
Frog   467 FEPLLTVPLNRTFPFSLQYICRAVICRSTTYDGIDLLPLPSMLQDFLKEYHYKQKVRVRWLER 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	74/99 (75%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	26/49 (53%)
socs5	NP_001016844.1	SOCS	145..195	CDD:372221	13/66 (20%)
		SH2	369..469	CDD:387587	74/99 (75%)
		SOCS	478..534	CDD:383010	26/52 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002657
OrthoInspector	1	1.000	-	-		otm49204
Panther	1	1.100	-	-	LDO	PTHR10155
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2417
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010