Protein Alignment Socs36E and Socs5

DIOPT Version :10

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_001102744.1
• Gene: Socs5 / 500616
• RGDID: 1564914
• Length: 536
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 186/560 - (33%)
• Similarity: 252/560 - (45%)
• Gaps: 119/560 - (21%)

  Fly   132 EGGYGEVGV---------VTNRTAGSSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNAN 187
            |||.....|         |..::......|.:.:..|:..| :|..:|.:.|......|....|.
  Rat    22 EGGSRSENVDMNANRCLSVKEKSVSLGEAAPRQQSSPLREN-IALQLGLSPSKTFSRRNQNCAAE 85

  Fly   188 CP--LEADDDDDLDESL---LRRRRSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPV 247
            .|  :|...:.|.|.|.   .|..|.:|.||        |.....:::|..
  Rat    86 IPQVVEISIEKDSDSSATPGTRLARRDSYSR--------HAPWGGKKKHSC-------------- 128

  Fly   248 SNMLSAGTQHSSKPVSRSNNSNSCCRSRS-----SKALSMGAATSSASGSASTSVSTSTSSKRRC 307
                |..||.|.....:...:.|..:.|.     |....|.:.:|.|.||             |.
  Rat   129 ----STKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMHDMDSVSSRAVGS-------------RS 176

  Fly   308 CKCKCRDAIRGL----RDMLPSSSSSVSNKK------------------DAAAVVAMVPRKSRTA 350
            .:.:.:|.: ||    |.....|....|||:                  |.|....::.:.:...
  Rat   177 LRQRLQDTV-GLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV 240

  Fly   351 DRRST-----PPTLGTSSGGSQRRMQSQRIRNSVAV---PDASHHHHQLIIRIT---------SP 398
            ...||     .|:|.::.....|..:.:|:.....|   |:|..|..:...::.         :|
  Rat   241 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAP 305

  Fly   399 GFVVESPNGGRVTVVTEPAPQSPQTPPRPRPLATV----------APAGGAGHAGIGAARNMTVH 453
            |....|.:|..:          |||.......:|.          ....|..|:.|.......||
  Rat   306 GMTEISGDGSAI----------PQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHSHISRQGAWKVH 360

  Fly   454 SQIDFMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRS 518
            :|||::|||||||.:||.:..|||.|||||||.||||||||||||||||||::||||:||:|.||
  Rat   361 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRS 425

  Fly   519 LHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRA 583
            |||||||..|.||||.||||||.:.||||||||||||:..|||||.|||.|:|...||||.:.||
  Rat   426 LHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRA 490

  Fly   584 TIVSNTSYDGINQMELPGRLKSYLKEYHYKQKLRVKPIDQ 623
            .|...|:||||:.:.||..|:.:|||||||||:||:.:::
  Rat   491 VICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLER 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:472789	76/99 (77%)
		SOCS	575..626	CDD:470605	26/49 (53%)
Socs5	NP_001102744.1	SOCS	145..195	CDD:432667	13/63 (21%)
		SH2	370..470	CDD:472789	76/99 (77%)
		SOCS_SOCS5	479..534	CDD:239708	26/52 (50%)