DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Socs36E and Socs6

DIOPT Version :9

Sequence 1:	NP_523593.5	Gene:	Socs36E / 35085	FlyBaseID:	FBgn0041184	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001258078.1	Gene:	Socs6 / 307200	RGDID:	1304632	Length:	547	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	127/558 - (22%)
Similarity:	200/558 - (35%)	Gaps:	159/558 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GSSPEAAKTERQPVNNNGLAGSVGAAISTLQLHDNHGGNANCPLEADDDDDLDESL-----LRRR 206
            ||..|..|...:   :..|.|::...:|..|.....||.      |..|:|...|.     |:..
  Rat    57 GSEDEKGKNRSK---SESLMGTLKRRLSAKQKTKGKGGT------APTDEDAFSSASAPGGLKDV 112

  Fly   207 RSNSNSRSNIHHHHHHHQQQQQQQHEAEVVEYCEVLESLPVSNMLSAGTQHSSKPVSRSNNSNSC 271
            |:....||.....||:                                 ..:..|:..:::..:|
  Rat   113 RAPRPIRSTSLRSHHY---------------------------------SPTPWPLRPTSSEETC 144

  Fly   272 CRSRSS-KALSMGAATSSASGSASTSVSTSTSSKRRCCKCKCRDAI--RGLRDMLP--------S 325
            .:.... |||...|:....:|.............|   ..:.|:.:  |.|||:.|        |
  Rat   145 IKMEMRVKALVHAASPGPVNGVRKELRELQPKELR---DLQPRELLQPRELRDLQPEPRPESRCS 206

  Fly   326 SSS----SVSNKKDAAAVVAMV--------------------PRK----SRTADRRSTPPTLGTS 362
            .||    |:..::....|:.::                    ||.    :.:....|..|..|.|
  Rat   207 PSSPGELSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGAS 271

  Fly   363 SGGSQRRMQSQRIRNSVAVPDASHHHHQLII-------------RITSPGFVVESPNGGRVTVVT 414
            ...|:               |.||....|::             .|.:.|.:::||.||.    .
  Rat   272 GTFSE---------------DDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGH----D 317

  Fly   415 EPAPQSPQTPP-RPRPLATVAPAGGAGHAGIGAARNMTVHSQID--------------------F 458
            :..|.||..|| :..|:.  ....|.....:..|.::..|...|                    .
  Rat   318 DAPPLSPLLPPMQNNPIQ--RNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMV 380

  Fly   459 MHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARI 523
            :..|..:|:|:....:|||.:.|:|||..|...|:|:||:|||:.:.:|.|::||.:|::||.||
  Rat   381 VTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 445

  Fly   524 EQSGHKFSFDCHDPCVFTAPTVTGLLEH-YKDPACVMF------------FEPCLTIPLHR-RQT 574
            |.|..:||| ...|.|....::..|:|| .:|.....|            :...||.|:.| .|.
  Rat   446 EHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQV 509

  Fly   575 FSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHY 612
            .|||.|.|..|...|..|.|.::.||.::|.||:|.||
  Rat   510 RSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	38/112 (34%)
Socs36E	NP_523593.5	SOCS	575..626	CDD:295349	17/38 (45%)
Socs6	NP_001258078.1	SH2_SOCS6	385..484	CDD:198250	38/99 (38%)
Socs6	NP_001258078.1	SOCS_SOCS6	507..547	CDD:239709	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740