Protein Alignment Socs36E and Socs1

DIOPT Version :10

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_034026.1
• Gene: Socs1 / 12703
• MGIID: 1354910
• Length: 212
• Species: Mus musculus
• Alignment Length: 219
• Identity: 63/219 - (28%)
• Similarity: 91/219 - (41%)
• Gaps: 49/219 - (22%)

  Fly   414 TEP----APQSPQTPPRPRPLATV-APAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSS 473
            :||    :..||..|.||||...| |||.|..|     .|....||          |..:||.:|
Mouse    23 SEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTH-----FRTFRSHS----------DYRRITRTS 72

  Fly   474 -------FYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKF- 530
                   ||||.:..:.|...|..:|.||||:|||.|....|:::.:........|:.....:|
Mouse    73 ALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFH 137

  Fly   531 ------SFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRATIVSNT 589
                  :|||          :..|||||     |......|..||.:|:...||:|.|..||:..
Mouse   138 LDGSRETFDC----------LFELLEHY-----VAAPRRMLGAPLRQRRVRPLQELCRQRIVAAV 187

  Fly   590 SYDGINQMELPGRLKSYLKEYHYK 613
            ..:.:.::.|...|:.||..:.::
Mouse   188 GRENLARIPLNPVLRDYLSSFPFQ 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:472789	31/113 (27%)
		SOCS	575..626	CDD:470605	10/39 (26%)
Socs1	NP_034026.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		14/31 (45%)
		Kinase inhibitory region (KIR)	56..67		4/20 (20%)
		Extended SH2 subdomain (ESS)	68..79		3/10 (30%)
		SH2_SOCS1	69..166	CDD:198245	30/111 (27%)
		SOCS	170..212	CDD:470605	11/42 (26%)
		Interaction with Elongin BC complex	174..183		4/8 (50%)