DRSC/TRiP Functional Genomics Resources

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Protein Alignment Socs36E and Socs1

DIOPT Version :9

Sequence 1:NP_523593.5 Gene:Socs36E / 35085 FlyBaseID:FBgn0041184 Length:737 Species:Drosophila melanogaster
Sequence 2:NP_001258532.1 Gene:Socs1 / 12703 MGIID:1354910 Length:212 Species:Mus musculus


Alignment Length:219 Identity:63/219 - (28%)
Similarity:91/219 - (41%) Gaps:49/219 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   414 TEP----APQSPQTPPRPRPLATV-APAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSS 473
            :||    :..||..|.||||...| |||.|..|     .|....||          |..:||.:|
Mouse    23 SEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTH-----FRTFRSHS----------DYRRITRTS 72

  Fly   474 -------FYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARIEQSGHKF- 530
                   ||||.:..:.|...|..:|.||||:|||.|....|:::.:........|:.....:| 
Mouse    73 ALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFH 137

  Fly   531 ------SFDCHDPCVFTAPTVTGLLEHYKDPACVMFFEPCLTIPLHRRQTFSLQQLSRATIVSNT 589
                  :|||          :..|||||     |......|..||.:|:...||:|.|..||:..
Mouse   138 LDGSRETFDC----------LFELLEHY-----VAAPRRMLGAPLRQRRVRPLQELCRQRIVAAV 187

  Fly   590 SYDGINQMELPGRLKSYLKEYHYK 613
            ..:.:.::.|...|:.||..:.::
Mouse   188 GRENLARIPLNPVLRDYLSSFPFQ 211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Socs36ENP_523593.5 SH2 463..563 CDD:301589 31/113 (27%)
SOCS 575..626 CDD:295349 10/39 (26%)
Socs1NP_001258532.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55 14/31 (45%)
Kinase inhibitory region (KIR) 56..67 4/20 (20%)
Extended SH2 subdomain (ESS) 68..79 3/10 (30%)
SH2_SOCS1 69..166 CDD:198245 30/111 (27%)
SOCS 170..212 CDD:295349 11/42 (26%)
Interaction with Elongin BC complex 174..183 4/8 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833075
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4566
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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