Protein Alignment Socs36E and Socs3

DIOPT Version :9

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_031733.1
• Gene: Socs3 / 12702
• MGIID: 1201791
• Length: 225
• Species: Mus musculus
• Alignment Length: 227
• Identity: 57/227 - (25%)
• Similarity: 87/227 - (38%)
• Gaps: 64/227 - (28%)

  Fly   435 PAGGAGHAGIGAARNMTVHSQIDFMHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLR 499
            ||.|.......:.|..|..|:.:: ..:|..:.|:..|.|||..:...||..||..:|.||||:|
Mouse     8 PAAGMSRPLDTSLRLKTFSSKSEY-QLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIR 71

  Fly   500 DSAQEEFLFSVTFRKYGRSLHARIEQSGHKFS-------------FDCHDPCVFTAPTVTGLLEH 551
            ||:.:...|:::.:....:.:.||:..|..||             |||          |..|:.|
Mouse    72 DSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDC----------VLKLVHH 126

  Fly   552 YKDPACVMFF-----EPCLTIP-----------------------------LHR---RQTFSLQQ 579
            |..|.....|     ||...:|                             |.|   ....:||.
Mouse   127 YMPPPGTPSFSLPPTEPSSEVPEQPPAQALPGSTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQH 191

  Fly   580 LSRATIVSN-TSYDGINQMELPGRLKSYLKEY 610
            |.|.|:..: .||:.:.|  |||.::.:|.:|
Mouse   192 LCRKTVNGHLDSYEKVTQ--LPGPIREFLDQY 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	33/117 (28%)
		SOCS	575..626	CDD:295349	13/37 (35%)
Socs3	NP_031733.1	Kinase inhibitory region (KIR)	22..33		2/11 (18%)
		Extended SH2 subdomain (ESS)	34..45		2/10 (20%)
		SH2_SOCS3	35..135	CDD:198247	32/109 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	131..160		4/28 (14%)
		SOCS_SOCS3	184..225	CDD:239706	13/40 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740