Protein Alignment Socs36E and CISH

DIOPT Version :9

• Sequence 1: NP_523593.5
• Gene: Socs36E / 35085
• FlyBaseID: FBgn0041184
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_037456.5
• Gene: CISH / 1154
• HGNCID: 1984
• Length: 275
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 64/258 - (24%)
• Similarity: 96/258 - (37%)
• Gaps: 70/258 - (27%)

  Fly   423 TP-PRPRPLATV----------------------APAG------GAGHAGIGAARNMTVHSQIDF 458
            || ||||||..|                      .|||      ..|......:....:..:.|.
Human    20 TPLPRPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDL 84

  Fly   459 MHCLVPDLEKITNSSFYWGKMDRYEAEHLLEGKPEGTFLLRDSAQEEFLFSVTFRKYGRSLHARI 523
            : |:......:..|.:|||.:...||...|:..||||||:|||....:||:::.:......:.||
Human    85 L-CIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRI 148

  Fly   524 EQSGHKFSFDCH---DPCVFTAPTVTGLLEHY------------KDPACVMFF---------EPC 564
            |.:...|..|.:   .|.:...|.|..|::||            .|||.....         :|.
Human   149 EYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPA 213

  Fly   565 LTIP--------------LHRRQTFSLQQLSRATIVSNTSYDGINQMELPGRLKSYLKEYHYK 613
            |..|              :.|....|||.|.|  :|.|.....::.:.||.|:..||::|.::
Human   214 LPAPPPATAVHLKLVQPFVRRSSARSLQHLCR--LVINRLVADVDCLPLPRRMADYLRQYPFQ 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Socs36E	NP_523593.5	SH2	463..563	CDD:301589	32/123 (26%)
		SOCS	575..626	CDD:295349	13/39 (33%)
CISH	NP_037456.5	SH2_CIS	94..181	CDD:198285	28/86 (33%)
		SOCS_CIS1	235..275	CDD:239703	13/42 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740