DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and Klhl1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_444335.2	Gene:	Klhl1 / 93688	MGIID:	2136335	Length:	751	Species:	Mus musculus

Alignment Length:	720	Identity:	266/720 - (36%)
Similarity:	382/720 - (53%)	Gaps:	67/720 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALSALLTKYTIGIMSNLSNGNSNNNN-------------QQQQQQQQGQNPQQPA---------Q 45
            ::||...|.:....|:.|:.:|.:::             .:.||...||..||||         :
Mouse    65 SVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLE 129

  Fly    46 NEGGAGAEFVAPPPGLGAAVGVAAMQQRNRLLQQQQQQHHHHQNPAAEGSGLERGSCLLRYASQN 110
            .|...|.:|..|             :.:...|::.|.:.........||.|....|.......|:
Mouse   130 EEVVTGMDFSGP-------------EDKGLALKELQAEPASSIQATGEGCGHRLTSTNHSLTPQS 181

  Fly   111 SLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVL 175
            .||.||.:..             |....|..:||..|....||:|||||||:..:.:|.|||:||
Mouse   182 DLDSSSSEEF-------------YQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVL 233

  Fly   176 ASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLT 239
            :|.|.||.||||| ..|::|..|.::.:|..||..|:.:.||..:|:.||.::.||.||.||||.
Mouse   234 SSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLP 298

  Fly   240 DVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVIS 304
            .|.:.||.||...|..|||||||.|||...|:||:..|.:|..::..|||:..|||.|..|::..
Mouse   299 QVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK 363

  Fly   305 LIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNI 369
            |:.:|.::||:||.::..::.|::||:..|....|:|:..:|||.|..:.:.. ::...|.:.::
Mouse   364 LLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPPQILAD-LENHALFKNDL 427

  Fly   370 VCKNLIIEALTYHLLP---TETKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKW 429
            .|:.||:||:.|||||   |..:|.||.||| .||   .|..:|| ...|...::|.||||...|
Mouse   428 ECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVG---TLYAVGGMDNNKGATTIEKYDLRTNLW 489

  Fly   430 YQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVL 494
            .||..|..||.:.|::|:.||::.:||.:|...:.||:.|:|.|..|.....|...|..|||.||
Mouse   490 IQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVL 554

  Fly   495 NGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCL 559
            .|.||||||.||.:.|::.|.:||::..|.::||||..||:|||..::|.||:|||.||  ..||
Mouse   555 EGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDG--SSCL 617

  Fly   560 SSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRS------VEAYDCETNS 618
            ||:|.|:|.|:.|...|.|..||.|.||...:..||||||||.|.....      ||.||.:|::
Mouse   618 SSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDT 682

  Fly   619 WRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVC 683
            |..||.:|..|...||......||.|||.||.:.|.::|.|.|.::.|..: |.:.|||:.|.|.
Mouse   683 WTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQM-ASLNIGRAGACVV 746

  Fly   684 MIDKP 688
            :|.:|
Mouse   747 VIKQP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	49/103 (48%)
		PHA03098	150..675	CDD:222983	225/536 (42%)
		BACK	258..359	CDD:285009	37/100 (37%)
		Kelch	405..449	CDD:128874	17/44 (39%)
		KELCH repeat	439..482	CDD:276965	14/42 (33%)
		Kelch	450..496	CDD:128874	17/45 (38%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		Kelch	497..543	CDD:128874	22/45 (49%)
		KELCH repeat	533..580	CDD:276965	24/46 (52%)
		Kelch	544..592	CDD:128874	23/47 (49%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	21/50 (42%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)
		Kelch	640..687	CDD:128874	19/46 (41%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..98		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..184		5/26 (19%)
		BTB	205..308	CDD:279045	48/102 (47%)
		PHA03098	209..731	CDD:222983	223/527 (42%)
		BACK	317..416	CDD:285009	37/98 (38%)
		Kelch 1	463..509		17/45 (38%)
		Kelch	464..509	CDD:128874	17/44 (39%)
		Kelch_1	498..543	CDD:279660	15/44 (34%)
		KELCH repeat	499..542	CDD:276965	14/42 (33%)
		Kelch 2	510..556		17/45 (38%)
		KELCH repeat	546..590	CDD:276965	22/43 (51%)
		Kelch	558..603	CDD:128874	22/44 (50%)
		Kelch 3	558..603		22/44 (50%)
		KELCH repeat	593..636	CDD:276965	23/44 (52%)
		Kelch	604..650	CDD:128874	23/47 (49%)
		Kelch 4	604..650		23/47 (49%)
		KELCH repeat	640..690	CDD:276965	21/49 (43%)
		Kelch	652..703	CDD:128874	21/50 (42%)
		Kelch 5	652..703		21/50 (42%)
		KELCH repeat	693..737	CDD:276965	16/44 (36%)
		Kelch 6	704..750		19/46 (41%)
		Kelch	704..748	CDD:128874	18/44 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820