DRSC/TRiP Functional Genomics Resources

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Protein Alignment kel and KBTBD6

DIOPT Version :9

Sequence 1:NP_476589.4 Gene:kel / 35084 FlyBaseID:FBgn0001301 Length:1477 Species:Drosophila melanogaster
Sequence 2:NP_690867.3 Gene:KBTBD6 / 89890 HGNCID:25340 Length:674 Species:Homo sapiens


Alignment Length:714 Identity:165/714 - (23%)
Similarity:274/714 - (38%) Gaps:181/714 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 SSQKHVQRPNGKERGTVGQY-------SNEQHTARSFDAMNEMRKQKQLCDVILVADDVEI---- 168
            :|.:..:||....:.||..:       .:..|:|.....:......:.||||     .:|:    
Human    14 ASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDV-----TIEVVTPG 73

  Fly   169 ---------HAHRMVLASCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNE 223
                     ..:|.|||:..|||.:||| ...||:||.:|:..|||.:.|:|:||.||..|.::|
Human    74 SGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSE 138

  Fly   224 DNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEV 288
            .||:.|..|:::|||..||:||..||..:||.:||..|.:|||.....:|.:.|::||.|:|.::
Human   139 ANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQL 203

  Fly   289 -----IQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLP 348
                 |:.:...:|:..|:::::..|.:.|.:|:.|....:.||......|....:.:.:.||..
Human   204 SHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWM 268

  Fly   349 FLSKE---YITQRVDKEILLEGNIVCKNLIIEALTYHLLPTETKSARTVPRKPVGMPKILLVIGG 410
            ..::|   |:...:.|.|:.:   .|.::|..||.........||...||.            ..
Human   269 HFTEEDQDYLEGLLTKPIVKK---YCLDVIEGALQMRYGDLLYKSLVPVPN------------SS 318

  Fly   411 QAPKAIRSVEWYDLREEKWYQAAEMPNRR---CRSGLSVL----GDKVYAVGGFNGSL------- 461
            .:..:..|:          ..|||.|.:|   |...:.:.    .|.......::|.|       
Human   319 SSSSSSNSL----------VSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPL 373

  Fly   462 ----RVRTVD-----------------------VYDPATDQWANCSNMEARRSTLGVAVLNGCIY 499
                ..|||.                       ||.||.:.|...::....|..:.||.|||.||
Human   374 TCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIY 438

  Fly   500 AVGGFDGTTG--LSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSV 562
            .:||.|..||  |...|.|:.|.:.|..:|.:.....|..:.|:...|||:.....|   |    
Human   439 ILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMF---C---- 496

  Fly   563 ERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSY 627
              |:|..:.|:....: .|.......|.|..:|.:  .|.|:::    .|:.....||.:.::..
Human   497 --YDPSHNMWLKCVSL-KRNDFQEACVFNEEIYCI--CDIPVMK----VYNPVRAEWRQMNNIPL 552

  Fly   628 C--RRNAGVVAHDGLLYVVGGDDGTS-------NLASVEVYCPDSDSW----------------- 666
            .  ..|..::.|...|.::     ||       |..:|..|....|.|                 
Human   553 VSETNNYRIIKHGQKLLLI-----TSRTPQWKKNRVTVYEYDIRGDQWINIGTTLGLLQFDSNFF 612

  Fly   667 ----RILPALMTIGRSYAGVCMIDKPMXMEEQGALARQAASLAIALLDDENSQAEGTMEGAIGG 726
                |:.|:.:..|:|:                            |.::|...:|.:.|..:||
Human   613 CLSARVYPSCLEPGQSF----------------------------LTEEEEIPSESSTEWDLGG 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kelNP_476589.4 BTB 147..250 CDD:279045 43/116 (37%)
PHA03098 150..675 CDD:222983 150/619 (24%)
BACK 258..359 CDD:285009 25/108 (23%)
Kelch 405..449 CDD:128874 7/50 (14%)
KELCH repeat 439..482 CDD:276965 13/83 (16%)
Kelch 450..496 CDD:128874 14/79 (18%)
KELCH repeat 486..530 CDD:276965 19/45 (42%)
Kelch 497..543 CDD:128874 15/47 (32%)
KELCH repeat 533..580 CDD:276965 10/46 (22%)
Kelch 544..592 CDD:128874 10/47 (21%)
KELCH repeat 582..626 CDD:276965 8/43 (19%)
Kelch 594..639 CDD:128874 8/46 (17%)
KELCH repeat 629..674 CDD:276965 12/72 (17%)
Kelch 640..687 CDD:128874 12/74 (16%)
KBTBD6NP_690867.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 3/13 (23%)
BTB_POZ_KBTBD6_7 37..178 CDD:349582 51/145 (35%)
PHA03098 55..553 CDD:222983 138/543 (25%)
BACK_KBTBD6_7 168..270 CDD:350557 26/101 (26%)
Kelch 1 386..435 9/48 (19%)
KELCH repeat 425..471 CDD:276965 19/45 (42%)
Kelch 2 436..484 15/47 (32%)
Kelch 3 486..523 10/46 (22%)
KELCH repeat 512..551 CDD:276965 9/44 (20%)
Kelch 4 524..564 7/45 (16%)
Kelch 5 567..616 8/53 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..674 5/18 (28%)
ATG8 interaction motif (AIM). /evidence=ECO:0000269|PubMed:25684205 668..671
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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