DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KBTBD8

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_115894.2	Gene:	KBTBD8 / 84541	HGNCID:	30691	Length:	601	Species:	Homo sapiens

Alignment Length:	553	Identity:	146/553 - (26%)
Similarity:	244/553 - (44%)	Gaps:	75/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ASQNSLDESSQKHVQRPNG-KERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVE-IH 169
            |:...|.:||    ..||| ..........:..|.......:..|..:.||.|:::..|..: ..
Human     2 AASADLSKSS----PTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFS 62

  Fly   170 AHRMVLASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAA 233
            .||.|||:.||||.:|||| ..||.|..:.:..|:|.:::|:::|.||:.|.:.|.|||.|.|||
Human    63 CHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAA 127

  Fly   234 NLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLS 298
            ::.|:..::|.|..::.:.||..|.:|:..|||.:...||.:.::.||.:.|..|.:..|||.|:
Human   128 SIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLT 192

  Fly   299 HEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMRE-QFTSLLMEHVRLPFLSKEYI------- 355
            .:|:||::.:|.::|..||.|||.:|.|..::...|| ....:..:.:|.|.:...:|
Human   193 KDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQF 257

  Fly   356 TQRVDKEILLEGNIVCKNLIIEALTYHLLPTETKSARTVPRKPVGMPKILLVI--------GGQA 412
            .|.:.|..:.:|                 |:.|...    .:.:||....::|        .|:.
Human   258 AQAIAKSCVEKG-----------------PSNTNGC----TQRLGMTASEMIICFDAAHKHSGKK 301

  Fly   413 PKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDK-VYAVGGFNGSLRVRTVD--------V 468
                ::|...|:...:.::..:.||.....|:.|..|. :|..||:..|....::|        :
Human   302 ----QTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWM 362

  Fly   469 YDPATDQWANCSNMEARRSTLGVAVLNGC--IYAVGG----FDGTTGLSSAEMYDPKTDIWRFIA 527
            ||.:|::|  .|.....|:.:|..::..|  :||:||    .||...|.|.|.||.:.:.|..:.
Human   363 YDHSTNRW--LSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVC 425

  Fly   528 SMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNN 592
            :|...............:|.:.| :.|.        .|.|..|.|..:..|:..|......|..:
Human   426 AMPVAMEFHNAVEYKEKIYVLQG-EFFL--------FYEPQKDYWGFLTPMTVPRIQGLAAVYKD 481

  Fly   593 ILYAVGGHDGPMVRR-SVEAYDCETNSWRSVAD 624
            .:|.:.|..|...|. :|||||.|.|.|....|
Human   482 SIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKD 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	39/104 (38%)
		PHA03098	150..675	CDD:222983	138/509 (27%)
		BACK	258..359	CDD:285009	32/108 (30%)
		Kelch	405..449	CDD:128874	8/51 (16%)
		KELCH repeat	439..482	CDD:276965	13/51 (25%)
		Kelch	450..496	CDD:128874	12/54 (22%)
		KELCH repeat	486..530	CDD:276965	15/49 (31%)
		Kelch	497..543	CDD:128874	14/51 (27%)
		KELCH repeat	533..580	CDD:276965	8/46 (17%)
		Kelch	544..592	CDD:128874	10/47 (21%)
		KELCH repeat	582..626	CDD:276965	15/44 (34%)
		Kelch	594..639	CDD:128874	13/32 (41%)
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
KBTBD8	NP_115894.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/26 (27%)
		BTB	39..144	CDD:279045	39/104 (38%)
		PHA03098	50..516	CDD:222983	135/501 (27%)
		BACK	153..250	CDD:285009	30/96 (31%)
		KELCH repeat	330..376	CDD:276965	12/47 (26%)
		Kelch 1. /evidence=ECO:0000255	336..390		12/55 (22%)
		Kelch	337..388	CDD:128874	12/52 (23%)
		Kelch_1	379..428	CDD:279660	14/48 (29%)
		KELCH repeat	380..428	CDD:276965	14/47 (30%)
		Kelch 2. /evidence=ECO:0000255	391..441		13/49 (27%)
		KELCH repeat	431..467	CDD:276965	7/44 (16%)
		Kelch 3. /evidence=ECO:0000255	443..481		10/46 (22%)
		Kelch_1	470..516	CDD:279660	15/45 (33%)
		Kelch 4. /evidence=ECO:0000255	483..532		13/32 (41%)
		KELCH repeat	519..571	CDD:276965
		Kelch 5. /evidence=ECO:0000255	542..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810