DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and gmcl1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001072725.1	Gene:	gmcl1 / 780182	XenbaseID:	XB-GENE-986541	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	411	Identity:	96/411 - (23%)
Similarity:	151/411 - (36%)	Gaps:	108/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ESSQKHVQRPNGKERGTVGQYSNEQHTARSFD-----AMNEMRKQK----------------QLC 157
            ||.||.|.....::|    :.|.|.|.....|     .:|..|::|                :..
Frog    12 ESKQKAVGSCEHRKR----KRSLECHCETETDEELENLLNTPRRKKLKSTSKYIYQTLFLNGENS 72

  Fly   158 DVILVADDVEIHAHRMVLASCSPYFYAMFT-SFEESRQARITLQ----SVDARALELLIDYVYTA 217
            |:.:.|...|...|::.|.. |.||.:||. |:.||....|.|:    ::||.||::....:|..
Frog    73 DIKICALGQEWSLHKIYLCQ-SGYFSSMFCGSWRESSMNVIELEIPDHNIDAEALQVAFGSLYRD 136

  Fly   218 TVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHA-------CVE-LL 274
            .|.:....|..:|.||.:|||..:...|.:.::..:.|....|....|.::.       |:| ||
Frog   137 DVLIKPSRVIAILAAACMLQLDGLIQQCGETMKETISAQTVCGYSSAAGVYGLDSVKKKCLEWLL 201

  Fly   275 NYAETYIEQHFNEVIQFDEFLNLS---HEQVISLIGNDRISVPNEERVYECVIAWLRYD-VP-MR 334
            |...|:        ...|.|..||   .||:|:  ..|.:.:..|..||..:..|:... || ..
Frog   202 NNLMTH--------QSVDLFKELSIGVMEQLIA--SPDLLVMQVEMDVYTALKKWMFLQLVPSWN 256

  Fly   335 EQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIV---CKN-----LIIEALTYHLLPTETKSA 391
            .....||.|       :..:.::| .|||  |.||.   |:.     .:...|....:.::..|.
Frog   257 GSLKQLLPE-------ADAWFSKR-RKEI--EENITFLECEQGSPFMPVFRHLRLQYIISDLASV 311

  Fly   392 RTVPRKPVGMPKILLVIGGQAPKAIRSVEWY-DLREEKWYQ--AAEMPN---------------- 437
            |.|.|..: :|.                ||. .:.:::|:.  .||..|
Frog   312 RIVERDCL-VPS----------------EWLSSIYKQQWFTMLRAEQDNDMGPQEISKDDLENNS 359

  Fly   438 RRCRSGLSVLGDKVYAVGGFN 458
            .||...|:..||..:...|||
Frog   360 MRCGRKLAKDGDYCWRWTGFN 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	32/123 (26%)
		PHA03098	150..675	CDD:222983	85/370 (23%)
		BACK	258..359	CDD:285009	25/113 (22%)
		Kelch	405..449	CDD:128874	9/62 (15%)
		KELCH repeat	439..482	CDD:276965	8/20 (40%)
		Kelch	450..496	CDD:128874	3/9 (33%)
		KELCH repeat	486..530	CDD:276965
		Kelch	497..543	CDD:128874
		KELCH repeat	533..580	CDD:276965
		Kelch	544..592	CDD:128874
		KELCH repeat	582..626	CDD:276965
		Kelch	594..639	CDD:128874
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
gmcl1	NP_001072725.1	BTB_POZ_GCL	57..171	CDD:349614	29/114 (25%)
gmcl1	NP_001072725.1	BACK_GCL	172..249	CDD:350570	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910