DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Klhl5

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_780383.2	Gene:	Klhl5 / 71778	MGIID:	1919028	Length:	708	Species:	Mus musculus

Alignment Length:	705	Identity:	275/705 - (39%)
Similarity:	382/705 - (54%)	Gaps:	64/705 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SNGNSNNNNQQQQQQQQGQNPQQPAQNEGGAGAEFVAPPPGLG---AAVGVAAMQQRNRLLQQQQ 81
            ::.||:.::||.:...:||.        |..|......|..|.   |::|.....|.:.......
Mouse    25 ASSNSSVDSQQGEFWNRGQT--------GANGGRKFLDPCNLQLPLASIGYRRSSQLDFQNSPSW 81

  Fly    82 QQHHHHQNPA----AEGSG----LER-----GSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQ 133
            ........||    |||..    |||     |:.    ..:|..|.||.:   ..|..:..:..|
Mouse    82 PMASTSDVPAFEFTAEGCAGAHWLERPEVDDGTS----EEENESDSSSSR---TSNSSQTLSSCQ 139

  Fly   134 -----YSNE-----QHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS 188
                 .|:|     .|..::|..|....:.||||||||||.|..|.|||:||:|.|.||.||||:
Mouse   140 AMEPCSSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN 204

  Fly   189 -FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQ 252
             ..|:||..|.::.|:..:|..||.|.||..:|:.|||::.||:.|.||||:.|.:|||.||..|
Mouse   205 DVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 269

  Fly   253 LDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEE 317
            |..|||||||.|||...|.:|...|..|..:||.|||:..||:.|...::..|:.:|.:::||||
Mouse   270 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPANEIAKLLASDDMNIPNEE 334

  Fly   318 RVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYH 382
            .:...::.|:|:|:..|.:..|.|:.::|||.|:.:::.. ::...|...:|.|:.||:||:.||
Mouse   335 TILNALLTWVRHDLEQRRKDLSRLLAYIRLPLLAPQFLAD-MENNALFRDDIECQKLIMEAMKYH 398

  Fly   383 LLPTE---TKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRS 442
            |||..   .:|.||.||| .||   .|..:|| .:.|...|:|.||||...|...|.|..||.:.
Mouse   399 LLPERRPMLQSPRTKPRKSTVG---TLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 460

  Fly   443 GLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGT 507
            |::||.||:|.|||.:|...:.||:.|:|.|..|:....|...|..||||||.|.:|||||.||.
Mouse   461 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW 525

  Fly   508 TGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTW 572
            :.|::.|.:||:...|.|:|:|||.||:|||.|:.|.||||||.||  ..||.|||.::|.|:.|
Mouse   526 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG--SSCLKSVECFDPHTNKW 588

  Fly   573 VNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRSVADMSYCRRN 631
            ...|:||.||.|.||...|.:|||:||||.|      .:...||.||.:|:.|.:||.||..|..
Mouse   589 TLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPTSNLTSRLSDCVERYDPKTDVWTAVASMSVSRDA 653

  Fly   632 AGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW-RILPALMTIGRSYAGVCMI 685
            .||......||.|||.||.:.|..||.|.|.::.| ::.|  :.:||  ||.|::
Mouse   654 VGVCLLGDKLYAVGGYDGQTYLNIVEAYDPQTNEWTQVAP--LCLGR--AGACVV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	53/103 (51%)
		PHA03098	150..675	CDD:222983	237/537 (44%)
		BACK	258..359	CDD:285009	36/100 (36%)
		Kelch	405..449	CDD:128874	18/44 (41%)
		KELCH repeat	439..482	CDD:276965	17/42 (40%)
		Kelch	450..496	CDD:128874	20/45 (44%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		Kelch	497..543	CDD:128874	23/45 (51%)
		KELCH repeat	533..580	CDD:276965	25/46 (54%)
		Kelch	544..592	CDD:128874	24/47 (51%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	21/50 (42%)
		KELCH repeat	629..674	CDD:276965	17/45 (38%)
		Kelch	640..687	CDD:128874	19/47 (40%)
Klhl5	NP_780383.2	BTB	163..266	CDD:279045	52/102 (51%)
		PHA03098	173..695	CDD:222983	234/529 (44%)
		BACK	275..374	CDD:285009	36/98 (37%)
		Kelch	422..467	CDD:128874	18/44 (41%)
		Kelch_1	456..501	CDD:279660	18/44 (41%)
		KELCH repeat	457..500	CDD:276965	17/42 (40%)
		KELCH repeat	504..548	CDD:276965	22/43 (51%)
		Kelch	517..561	CDD:128874	23/43 (53%)
		KELCH repeat	551..594	CDD:276965	24/44 (55%)
		Kelch	562..608	CDD:128874	24/47 (51%)
		Kelch_1	597..648	CDD:279660	22/50 (44%)
		KELCH repeat	598..648	CDD:276965	21/49 (43%)
		Kelch_1	651..694	CDD:279660	17/44 (39%)
		KELCH repeat	651..694	CDD:276965	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820