DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and klhl5

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001164413.1	Gene:	klhl5 / 560697	ZFINID:	ZDB-GENE-080424-7	Length:	769	Species:	Danio rerio

Alignment Length:	715	Identity:	279/715 - (39%)
Similarity:	390/715 - (54%)	Gaps:	77/715 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SNGN-SNNNNQQQQQQQQGQN---------------PQQPAQNE--GGAGAEFVAPPPGLGAAVG 66
            |||| |:|.|..::....|.|               |:..:|.|  ....|.:|.|... .::..
Zfish    79 SNGNLSSNINNSRKFGDSGPNSGHSAAAVVISGTACPRSMSQQECRSSPPAPWVFPVHS-RSSES 142

  Fly    67 VAAMQQRNRLLQQQQQQHHHHQNPAAEGSGLER---------GSCLLRYASQNSLDES------- 115
            :..:||:.:..|||.|:....:.|.|.|.|.|.         .||   ..|.:|:..|
Zfish   143 LEPLQQQPQQPQQQPQKQQSTRAPDASGPGDEENNNNVESDSSSC---RTSNSSVTLSSCASMEP 204

  Fly   116 --SQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASC 178
              |.:|.|           .:|:.:||.|..:|....||   ||||:|:|.|..|.|||:||:|.
Zfish   205 CVSDEHFQ-----------AHSHAEHTFRRMEAYLRTRK---LCDVVLLAGDRRIPAHRLVLSSV 255

  Fly   179 SPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVR 242
            |.||.||||| ..|::|..|.::.||..||.:|:.|.||..:|:.||.::.||:.:.||||:.|.
Zfish   256 SDYFAAMFTSDVREAKQEEIKMEGVDPDALWVLVQYAYTGRLELREDTIESLLSGSCLLQLSAVV 320

  Fly   243 DACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIG 307
            .|||.:|..||..|||||||.|||...|::|...|..|..:||.||::..|||.|...:|..|:.
Zfish   321 QACCSYLMKQLHPSNCLGIRSFADAQGCLDLHKVAHNYTMEHFMEVMRHQEFLLLPSCEVEKLLA 385

  Fly   308 NDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCK 372
            :|.::||.||.|...:::|:|:||..|:...|.|:.|:|||.|..:::.. ::...||..::.|:
Zfish   386 SDDMNVPEEETVVTALLSWVRHDVTTRQSQLSALLAHIRLPLLKPQFLAD-MEANPLLRDSVECQ 449

  Fly   373 NLIIEALTYHLLPTE---TKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQA 432
            .|::||:.|||||..   .:|.||.||| .||   .|..:|| .|.|...|:|.|.||.:.|.|.
Zfish   450 RLVMEAMKYHLLPERRPLLQSPRTRPRKATVG---ALFAVGGMDATKGATSIEQYCLRRDTWRQV 511

  Fly   433 AEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGC 497
            |.|..||.:.|::||.|::|.|||.:|...:.||:.|:|.:..|:....|...|..||||||.|.
Zfish   512 AVMSGRRLQFGVAVLDDRLYVVGGRDGLKTLNTVECYNPRSKSWSVMPPMSTHRHGLGVAVLEGP 576

  Fly   498 IYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSV 562
            :|||||.||.:.||:.|.:||:...|.|:|||:|.||:|||.|::..||||||.||  ..||.||
Zfish   577 MYAVGGHDGWSYLSTVERWDPQARQWSFVASMATPRSTVGVAVLNSKLYAVGGRDG--SSCLKSV 639

  Fly   563 ERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRS 621
            |.::|.|:.|.:.|.||.||.|.||...|..|||:||||.|      .:...||.||.:|:.|.:
Zfish   640 ECFDPHTNKWSSCAPMSKRRGGVGVATWNGFLYAIGGHDAPASSLASRLSDCVERYDPKTDMWTA 704

  Fly   622 VADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW-RILPALMTIGRSYAGVCMI 685
            ||.||..|...||......||.|||.||...|.:||.|.|.::.| ::.|  :.:||  ||.|::
Zfish   705 VAPMSLSRDAVGVCLLGDRLYAVGGYDGQVYLNTVEAYDPQTNEWTQVAP--LCLGR--AGACVV 765

Fly 686 685
Zfish 766 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	48/103 (47%)
		PHA03098	150..675	CDD:222983	235/537 (44%)
		BACK	258..359	CDD:285009	40/100 (40%)
		Kelch	405..449	CDD:128874	19/44 (43%)
		KELCH repeat	439..482	CDD:276965	15/42 (36%)
		Kelch	450..496	CDD:128874	18/45 (40%)
		KELCH repeat	486..530	CDD:276965	24/43 (56%)
		Kelch	497..543	CDD:128874	24/45 (53%)
		KELCH repeat	533..580	CDD:276965	24/46 (52%)
		Kelch	544..592	CDD:128874	24/47 (51%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	21/50 (42%)
		KELCH repeat	629..674	CDD:276965	17/45 (38%)
		Kelch	640..687	CDD:128874	19/47 (40%)
klhl5	NP_001164413.1	BTB	224..327	CDD:279045	49/105 (47%)
		PHA03098	225..756	CDD:222983	236/541 (44%)
		BACK	336..435	CDD:285009	40/98 (41%)
		Kelch	483..528	CDD:128874	19/44 (43%)
		KELCH repeat	518..561	CDD:276965	15/42 (36%)
		Kelch	529..575	CDD:128874	18/45 (40%)
		KELCH repeat	565..609	CDD:276965	24/43 (56%)
		Kelch	578..621	CDD:128874	24/42 (57%)
		KELCH repeat	612..655	CDD:276965	23/44 (52%)
		Kelch	623..669	CDD:128874	24/47 (51%)
		KELCH repeat	659..709	CDD:276965	21/49 (43%)
		Kelch	671..722	CDD:128874	21/50 (42%)
		KELCH repeat	712..755	CDD:276965	17/44 (39%)
		Kelch	723..767	CDD:128874	19/47 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820