DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KLHL4

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_476503.1	Gene:	KLHL4 / 56062	HGNCID:	6355	Length:	720	Species:	Homo sapiens

Alignment Length:	688	Identity:	252/688 - (36%)
Similarity:	365/688 - (53%)	Gaps:	59/688 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GNSNNNN--QQQQQQQQGQNPQ----QPAQNEGG-------AGAEFVAPPPGLGAA--VGVAAMQ 71
            |::|..:  ||:..:.:|...|    ..:::..|       .....:||.||...|  ..|..:|
Human    28 GSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQ 92

  Fly    72 QRNRLLQQQQQQHHHHQNP-------AAEGSGLERGSCLLRYASQNSLDESSQ---KHVQRPNGK 126
            |.|.::..|..:......|       |.|    :|...|...|..|..|.:::   :|.:..|..
Human    93 QHNLIVHFQANEDTPKSVPEKNLFKEACE----KRAQDLEMMADDNIEDSTARLDTQHSEDMNAT 153

  Fly   127 ERGTVGQYSNEQ-----HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMF 186
            .       |.||     |..::...|....|:||||||:|:|..:.|.|||:||::.|.||.|||
Human   154 R-------SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMF 211

  Fly   187 TS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQ 250
            |: ..|::|..:.::.||..||..|:.|.||..:::.||.::.||.||.|||||.|.|.|.:||.
Human   212 TNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLI 276

  Fly   251 TQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPN 315
            .||..|||||||.|.|...|.||||.|..|..:||.|||:..|||.|...::..|:.:|.|:||:
Human   277 KQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341

  Fly   316 EERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALT 380
            ||.::..::.|:.:||..|:....:|:.::|||.|..:.:.. ::...:..|::.|:.|::||:.
Human   342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMK 405

  Fly   381 YHLLP---TETKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRC 440
            |||||   :..:|.||.||| .||   .|..:|| .|.|...::|.||||...|.....|..||.
Human   406 YHLLPERRSMMQSPRTKPRKSTVG---ALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467

  Fly   441 RSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFD 505
            :.|::|:.:|:|.|||.:|...:.||:.::|....|.....|...|..||||.|.|.:|||||.|
Human   468 QFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD 532

  Fly   506 GTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTD 570
            |.:.|::.|.:||:...|.::|||||.||:|||..::..|||:||.||  ..||.|:|.::|.|:
Human   533 GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG--SSCLKSMEYFDPHTN 595

  Fly   571 TWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRSVADMSYCR 629
            .|...|.||.||.|.||...|..||.|||||.|      .:...||.||.:.:||.:||.:|..|
Human   596 KWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660

  Fly   630 RNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWR 667
            ....|......||||||.||.:.|.:||.|....:.|:
Human   661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	48/103 (47%)
		PHA03098	150..675	CDD:222983	220/530 (42%)
		BACK	258..359	CDD:285009	39/100 (39%)
		Kelch	405..449	CDD:128874	16/44 (36%)
		KELCH repeat	439..482	CDD:276965	13/42 (31%)
		Kelch	450..496	CDD:128874	17/45 (38%)
		KELCH repeat	486..530	CDD:276965	21/43 (49%)
		Kelch	497..543	CDD:128874	22/45 (49%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	22/47 (47%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	19/50 (38%)
		KELCH repeat	629..674	CDD:276965	15/39 (38%)
		Kelch	640..687	CDD:128874	13/28 (46%)
KLHL4	NP_476503.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..69		2/22 (9%)
		BTB	172..276	CDD:279045	48/103 (47%)
		PHA03098	176..698	CDD:222983	219/527 (42%)
		BACK	284..373	CDD:285009	35/88 (40%)
		Kelch 1	430..476		16/45 (36%)
		Kelch	431..476	CDD:128874	16/44 (36%)
		Kelch_1	465..510	CDD:279660	14/44 (32%)
		KELCH repeat	466..509	CDD:276965	13/42 (31%)
		Kelch 2	477..523		17/45 (38%)
		KELCH repeat	513..557	CDD:276965	21/43 (49%)
		Kelch 3	525..570		22/44 (50%)
		Kelch	526..570	CDD:128874	22/43 (51%)
		KELCH repeat	560..603	CDD:276965	20/44 (45%)
		Kelch	571..617	CDD:128874	22/47 (47%)
		Kelch 4	571..617		22/47 (47%)
		KELCH repeat	607..658	CDD:276965	21/50 (42%)
		Kelch	619..670	CDD:128874	19/50 (38%)
		Kelch 5	619..670		19/50 (38%)
		Kelch_1	659..702	CDD:279660	15/40 (38%)
		KELCH repeat	660..699	CDD:276965	15/39 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820