Protein Alignment kel and KLHL7

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001026880.2
• Gene: KLHL7 / 55975
• HGNCID: 15646
• Length: 586
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 195/602 - (32%)
• Similarity: 302/602 - (50%)
• Gaps: 41/602 - (6%)

  Fly   110 NSLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMV 174
            :.:::||:|..::       .:......:..|.....||.|||||.||||||:..:.:|.|||:|
Human     4 SGVEKSSKKKTEK-------KLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVV 61

  Fly   175 LASCSPYFYAMF-TSFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQL 238
            ||:.|.:|..|| |:..||:...:.|:..:...:|.|:::.|||.:.||.:|||.||.|||..|:
Human    62 LAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQI 126

  Fly   239 TDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVI 303
            ..|:..|.|||:.|:||||||||...|:...|.||...|:.:|.|||.||.:.||||.|..::|.
Human   127 EPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVT 191

  Fly   304 SLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGN 368
            .|:..|.::|..|::||:..:.||:||.|.|:.|...::..||.|.:||.::::.|..|.|::.|
Human   192 HLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDN 256

  Fly   369 IVCKNLIIEALTYHLLPTETKSA---RTVPRKPVGMPKILLVIGGQAPKAIR-----SVEWYDLR 425
            ..|..::|..:.||||..|.:..   .|.||:.....:|.| .||..|::.|     ...|.|:|
Human   257 PECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIAL-FGGSQPQSCRYFNPKDYSWTDIR 320

  Fly   426 EEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLG 490
                     .|..:.|....|..|.|..:.|.:....::.:|.|:...|.|.:.......|.:|.
Human   321 ---------CPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLA 376

  Fly   491 VAVLNGCIYAVGGFD-GTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDG- 553
            .....|.||..||.: |.:.|...|.||.:|:.|....||.|:|.|.|:...:||:|..||..|
Human   377 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGN 441

  Fly   554 -FTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETN 617
             .:.:.|:|.|.|:|.|:||..:..|...|...|:..:.:.::||||.:|.....:||.||.:.|
Human   442 NVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLN 506

  Fly   618 SWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW------RILPALMTIG 676
            .|:.|:.|.:........|...::||:.|..|...|..:..|..::|.|      |..|....:
Human   507 EWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCL- 570

  Fly   677 RSYAGVCMIDKPMXMEE 693
                 :|::|.....||
Human   571 -----ICVVDTCGANEE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	51/119 (43%)
		PHA03098	150..675	CDD:222983	185/542 (34%)
		KELCH repeat	439..482	CDD:276965	9/42 (21%)
		KELCH repeat	486..530	CDD:276965	15/44 (34%)
		KELCH repeat	533..580	CDD:276965	18/48 (38%)
		KELCH repeat	582..626	CDD:276965	14/43 (33%)
		KELCH repeat	629..674	CDD:276965	11/50 (22%)
KLHL7	NP_001026880.2	BTB_POZ_KLHL7	23..148	CDD:349546	56/124 (45%)
		PHA03098	37..555	CDD:222983	182/527 (35%)
		BACK_KLHL7	140..237	CDD:350522	41/96 (43%)
		Kelch 1	294..336		12/51 (24%)
		Kelch 2	337..382		8/44 (18%)
		KELCH repeat	372..416	CDD:276965	14/43 (33%)
		Kelch 3	383..430		17/46 (37%)
		KELCH repeat	420..468	CDD:276965	17/47 (36%)
		Kelch 4	431..481		16/49 (33%)
		KELCH repeat	471..515	CDD:276965	14/43 (33%)
		Kelch 5	483..528		14/44 (32%)
		Kelch 6	530..575		11/50 (22%)