DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and klhl40a

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001122154.1	Gene:	klhl40a / 553257	ZFINID:	ZDB-GENE-050916-1	Length:	612	Species:	Danio rerio

Alignment Length:	587	Identity:	162/587 - (27%)
Similarity:	261/587 - (44%)	Gaps:	77/587 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SFDAMNEMRKQKQ------LCDV---------ILVADDVEIHAHRMVLASCSPYFYAMFTS-FEE 191
            |.|.:.|.|..:|      |||:         ||...|.|...||:|||:.||||.|||.| .||
Zfish     5 SVDPVTEPRMYQQTLLQDGLCDLLDANKFVDCILKIKDKEFPCHRLVLAATSPYFKAMFLSDLEE 69

  Fly   192 SRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDAS 256
            |::..|.|:.::...:.:::.|:||:.:.:.|.|||.:..|||:.|:..:...|..:||.:|..|
Zfish    70 SKKREIVLKDIEPGIMGMILRYIYTSDINLTEQNVQDIFMAANMYQIPSIFSVCVSYLQQKLVLS 134

  Fly   257 NCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYE 321
            |||.|.....:..|..|...|..:|...:..:|:..:|..|...::.::|..|.::|..||.|:|
Zfish   135 NCLAIFRLGLLLDCPRLAMEARDFICDRYLLIIRDQDFHQLGPSELAAIITCDSLNVEREESVFE 199

  Fly   322 CVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCK---NLIIEA---LT 380
            .::.|:.||...|.:....|:..||...:...|..::|:...|:..|...|   .||.:|   |.
Zfish   200 SLMDWVEYDTDERTKELPELLHCVRFRLMPTSYFKEKVEGHRLIRTNQELKKELQLIKDAQKGLL 264

  Fly   381 YHLLPT----ETKSA-----------------RTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDL 424
            :.:..:    |.|||                 ...||..:....::|:|......|      ||:
Zfish   265 HRVKRSSHRKEGKSAEFESDDDDEDGLLPGILNDNPRFGMFQSDLILMINDAGTVA------YDV 323

  Fly   425 REEKWYQAA---EMPNRRCRSGLSVLGDKVYAVGG--FNGSLRVRTVDVY----DPATDQWANCS 480
            ...:.:.|:   |:|...|  .|....::::.|||  :|...:.:....|    ||.:.:|....
Zfish   324 GANECFVASSSTEIPKNHC--SLVTKENQIFVVGGLRYNEENKDQPFSSYFLQFDPMSSEWLGMP 386

  Fly   481 NMEARRSTLGVAVLNGCIYAVGG---FDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVV- 541
            ::...|...|:......||.|||   .:|...|.|..:||.::..|.  .|.....:..|.|:|
Zfish   387 SLPNPRCLFGLVEAENSIYVVGGKELKEGERALDSVMIYDRQSFKWG--ESDPLPYAVYGHGIVS 449

  Fly   542 -HGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMV 605
             .||:|.:||... :::||..|..|:|....|.::|.|.:.||..|..|..|.:|.|.|.....:
Zfish   450 HKGLVYVIGGKTE-SKKCLRRVCVYDPSKFEWKDLAPMKTARSLFGTAVHKNKIYVVTGVTDNGL 513

  Fly   606 RRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGG-----DDGTSNLASVEVYCPDSDS 665
            ..:||.||..:|||....|....|.:..:|...|.||.:||     ::.|..|...|:    :|.
Zfish   514 TSTVEVYDIASNSWSEFVDFPQERSSLNLVELGGFLYAIGGFAMMPNETTEKLEPTEM----NDI 574

  Fly   666 WR 667
            |:
Zfish   575 WK 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	40/118 (34%)
		PHA03098	150..675	CDD:222983	159/580 (27%)
		BACK	258..359	CDD:285009	25/100 (25%)
		Kelch	405..449	CDD:128874	10/46 (22%)
		KELCH repeat	439..482	CDD:276965	10/48 (21%)
		Kelch	450..496	CDD:128874	10/51 (20%)
		KELCH repeat	486..530	CDD:276965	14/46 (30%)
		Kelch	497..543	CDD:128874	15/50 (30%)
		KELCH repeat	533..580	CDD:276965	16/48 (33%)
		Kelch	544..592	CDD:128874	16/47 (34%)
		KELCH repeat	582..626	CDD:276965	16/43 (37%)
		Kelch	594..639	CDD:128874	13/44 (30%)
		KELCH repeat	629..674	CDD:276965	12/44 (27%)
		Kelch	640..687	CDD:128874	9/33 (27%)
klhl40a	NP_001122154.1	BTB	26..128	CDD:279045	35/101 (35%)
		PHA03098	48..540	CDD:222983	139/502 (28%)
		BACK	136..236	CDD:197943	25/99 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..290		4/23 (17%)
		KELCH repeat	341..388	CDD:276965	10/48 (21%)
		Kelch 1	350..402		10/51 (20%)
		Kelch	350..398	CDD:128874	10/47 (21%)
		Kelch_1	391..432	CDD:279660	12/40 (30%)
		KELCH repeat	392..438	CDD:276965	14/47 (30%)
		Kelch 2	403..452		15/50 (30%)
		KELCH repeat	442..487	CDD:276965	15/45 (33%)
		Kelch	453..500	CDD:128874	16/47 (34%)
		Kelch 3	453..500		16/47 (34%)
		Kelch_1	489..529	CDD:279660	15/39 (38%)
		KELCH repeat	490..535	CDD:276965	16/44 (36%)
		Kelch 4	502..547		13/44 (30%)
		Kelch 5	549..604		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810