Protein Alignment kel and Klhl33

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001357693.1
• Gene: Klhl33 / 546611
• MGIID: 3644593
• Length: 793
• Species: Mus musculus
• Alignment Length: 704
• Identity: 163/704 - (23%)
• Similarity: 270/704 - (38%)
• Gaps: 122/704 - (17%)

  Fly    62 GAAVGV-----AAMQQ--RNRLLQQQQQQHHHHQNPAAEGSGLERG-SCLLRYASQNSLDESSQK 118
            |...||     ||:..  |.|||....||      |:.......|| ...|.:|.:..|..:||.
Mouse   117 GQVYGVHRVILAAISSLFRGRLLSGGGQQ------PSFSLDVTPRGWEAALTFAYEGVLGPASQD 175

  Fly   119 HV-----------------QRPN--GKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVAD 164
            .|                 .:|.  ||.||...:.|..:....:..::..:.::...||:.|.|:
Mouse   176 EVLAAAEALGAPRVKKAAQLKPEGLGKARGNEKKLSQAEELRENLHSIERLYREGIGCDLELEAE 240

  Fly   165 DVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQV 228
            ...:..||:.||..|.:|.||..| ..||:..::||:::.::.|.||:.:.||..|......:..
Mouse   241 GYRLRVHRVALACGSEFFGAMLLSGMRESQGTKVTLRTISSQDLRLLVSFAYTGVVRERWPGLLR 305

  Fly   229 LLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDE 293
            ...||...|.:...|.|...|...|..:.||.:....:.....::...|..|:..|...|.....
Mouse   306 AAQAALQYQSSSCLDLCQKALAQSLCPALCLALFPMIEAPGLEKVWGKAHDYLLSHLPAVASCPT 370

  Fly   294 FLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQ- 357
            |.:|....:..|:.:|.:.|..|...:.....||..:....|.....|:..||...:|...:.:
Mouse   371 FSSLPVTCLAELLDSDELHVQEEFEAFSAARCWLAANPETHESEAKALLRCVRFGRMSTRELRKV 435

  Fly   358 -------RVDKEILLEGNIVCKNLIIEALTYHLLPTETKSARTVP-----RKPVGMPKILLVIGG 410
                   .:..::|.:       |::||              .||     |:|   .:.|:||||
Mouse   436 RAAGLPPSLPPDLLYQ-------LMVEA--------------EVPGQERWREP---DQALVVIGG 476

  Fly   411 QAPK-----------------------AIRSVEWYDLREEKWYQAAEMPN----RRCRSG-LSVL 447
            ...:                       .:|:|||           ..:||    .|.|.| .|:.
Mouse   477 DGLRPDMDRRQPSCKVWWARAFHCGMGLVRTVEW-----------CRLPNLPAPGRFRHGAASLT 530

  Fly   448 GDKVYAVGG---FNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTG 509
            |.::|..||   ::.:..:.:...:..:.:.|...:.:...||...:.|.:|.:||:||.|....
Mouse   531 GSELYVCGGQDFYSHNSTLASTLRWSSSQEDWEEMAPLCQARSFFPLVVFDGQLYALGGRDNGVA 595

  Fly   510 LSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTD-TWV 573
            |:|.|.|:|:.::||...::.....:....::...||..||..| |.|.|.|:..|:|... ...
Mouse   596 LNSVETYNPELNVWRPAPALPAPCFAHAAAILEDRLYVSGGCSG-TGQYLDSLIHYDPKLKRPGT 659

  Fly   574 NVAEMSSRRSGAGVGVLNNILYAVG--GHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVA 636
            .::.|...|:...:..|...||..|  |..|.::  |.|||:.:::||..:|.:......|....
Mouse   660 LLSPMGVARASHVMAALGGKLYVAGGVGDTGDLL--SFEAYEPKSDSWTQLASLPSPHVGAAGAV 722

  Fly   637 HDGLLYVVGGDDGTSNLAS--VEVYCPDSDSWRILPALMTIGRSYAGVCMIDKP 688
            ..|.|.|:||....:...|  |..|||..|.|..|..|.. .|:....|::..|
Mouse   723 LQGELLVLGGYSHRTYAISHLVHAYCPGLDRWLCLGTLPR-PRAEMPACILTLP 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	30/119 (25%)
		PHA03098	150..675	CDD:222983	134/574 (23%)
		KELCH repeat	439..482	CDD:276965	9/46 (20%)
		KELCH repeat	486..530	CDD:276965	16/43 (37%)
		KELCH repeat	533..580	CDD:276965	12/47 (26%)
		KELCH repeat	582..626	CDD:276965	14/45 (31%)
		KELCH repeat	629..674	CDD:276965	15/46 (33%)
Klhl33	NP_001357693.1	BTB_POZ	91..189	CDD:453885	20/77 (26%)
		BTB_POZ	220..337	CDD:453885	31/116 (27%)
		BACK	335..435	CDD:197943	19/99 (19%)
		NanM	508..770	CDD:442289	72/276 (26%)
		KELCH repeat	521..569	CDD:276965	9/47 (19%)
		KELCH repeat	572..615	CDD:276965	16/42 (38%)
		KELCH repeat	619..665	CDD:276965	11/46 (24%)
		KELCH repeat	668..713	CDD:276965	14/46 (30%)
		KELCH repeat	715..761	CDD:276965	14/45 (31%)