Protein Alignment kel and KLHL5

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: XP_047271704.1
• Gene: KLHL5 / 51088
• HGNCID: 6356
• Length: 804
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 267/686 - (38%)
• Similarity: 367/686 - (53%)
• Gaps: 61/686 - (8%)

  Fly    20 SNGNSNNNNQQQQQQQQGQNPQQPAQNEGGAGAEFVAPPPGLG---AAVGVAAMQQRNRLLQQQQ 81
            |:.||..::||.:...:||.        |..|......|..|.   |::|.....|.:.......
Human   106 SSPNSTVDSQQGEFWNRGQT--------GANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSW 162

  Fly    82 QQHHHHQNPA----AEGSG----LER----------------GSCLLRYASQNSLDESSQKHVQR 122
            ......:.||    ||..|    |:|                .||    .:.||....|..|...
Human   163 PMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSC----RTSNSSQTLSSCHTME 223

  Fly   123 PNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFT 187
            |...:.    .:....|..::|..|....:.||||||||||.|..|.|||:||:|.|.||.||||
Human   224 PCTSDE----FFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT 284

  Fly   188 S-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQT 251
            : ..|:||..|.::.|:..:|..||.|.||..:|:.|||::.||:.|.||||:.|.:|||.||..
Human   285 NDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 349

  Fly   252 QLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNE 316
            ||..|||||||.|||...|.:|...|..|..:||.|||:..||:.|...::..|:.:|.:::|||
Human   350 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 414

  Fly   317 ERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTY 381
            |.:...::.|:|:|:..|.:..|.|:.::|||.|:.:::.. ::..:|...:|.|:.||:||:.|
Human   415 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKY 478

  Fly   382 HLLPTE---TKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRCR 441
            ||||..   .:|.||.||| .||   .|..:|| .:.|...|:|.||||...|...|.|..||.:
Human   479 HLLPERRPMLQSPRTKPRKSTVG---TLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQ 540

  Fly   442 SGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDG 506
            .|::||.||:|.|||.:|...:.||:.|:|.|..|:....|...|..||||||.|.:|||||.||
Human   541 FGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 605

  Fly   507 TTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDT 571
            .:.|::.|.:||:...|.|:|:|||.||:|||.|:.|.||||||.||  ..||.|||.::|.|:.
Human   606 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG--SSCLKSVECFDPHTNK 668

  Fly   572 WVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRSVADMSYCRR 630
            |...|:||.||.|.||...|.:|||:||||.|      .:...||.||.:|:.|.:||.||..|.
Human   669 WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 733

  Fly   631 NAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW 666
            ..||......||.|||.||.:.|.:||.|.|.::.|
Human   734 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	58/119 (49%)
		PHA03098	150..675	CDD:222983	236/529 (45%)
		KELCH repeat	439..482	CDD:276965	17/42 (40%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		KELCH repeat	533..580	CDD:276965	25/46 (54%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		KELCH repeat	629..674	CDD:276965	16/38 (42%)
KLHL5	XP_047271704.1	PHA03098	254..775	CDD:222983	233/522 (45%)
		KELCH repeat	538..581	CDD:276965	17/42 (40%)
		KELCH repeat	585..629	CDD:276965	22/43 (51%)
		KELCH repeat	632..675	CDD:276965	24/44 (55%)
		KELCH repeat	679..729	CDD:276965	21/49 (43%)
		KELCH repeat	732..772	CDD:276965	16/38 (42%)