DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and KLHL5

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_011512001.1	Gene:	KLHL5 / 51088	HGNCID:	6356	Length:	804	Species:	Homo sapiens

Alignment Length:	686	Identity:	267/686 - (38%)
Similarity:	367/686 - (53%)	Gaps:	61/686 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SNGNSNNNNQQQQQQQQGQNPQQPAQNEGGAGAEFVAPPPGLG---AAVGVAAMQQRNRLLQQQQ 81
            |:.||..::||.:...:||.        |..|......|..|.   |::|.....|.:.......
Human   106 SSPNSTVDSQQGEFWNRGQT--------GANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSW 162

  Fly    82 QQHHHHQNPA----AEGSG----LER----------------GSCLLRYASQNSLDESSQKHVQR 122
            ......:.||    ||..|    |:|                .||    .:.||....|..|...
Human   163 PMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSC----RTSNSSQTLSSCHTME 223

  Fly   123 PNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFT 187
            |...:.    .:....|..::|..|....:.||||||||||.|..|.|||:||:|.|.||.||||
Human   224 PCTSDE----FFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT 284

  Fly   188 S-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQT 251
            : ..|:||..|.::.|:..:|..||.|.||..:|:.|||::.||:.|.||||:.|.:|||.||..
Human   285 NDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 349

  Fly   252 QLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNE 316
            ||..|||||||.|||...|.:|...|..|..:||.|||:..||:.|...::..|:.:|.:::|||
Human   350 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 414

  Fly   317 ERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTY 381
            |.:...::.|:|:|:..|.:..|.|:.::|||.|:.:::.. ::..:|...:|.|:.||:||:.|
Human   415 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKY 478

  Fly   382 HLLPTE---TKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRRCR 441
            ||||..   .:|.||.||| .||   .|..:|| .:.|...|:|.||||...|...|.|..||.:
Human   479 HLLPERRPMLQSPRTKPRKSTVG---TLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQ 540

  Fly   442 SGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDG 506
            .|::||.||:|.|||.:|...:.||:.|:|.|..|:....|...|..||||||.|.:|||||.||
Human   541 FGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG 605

  Fly   507 TTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDT 571
            .:.|::.|.:||:...|.|:|:|||.||:|||.|:.|.||||||.||  ..||.|||.::|.|:.
Human   606 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG--SSCLKSVECFDPHTNK 668

  Fly   572 WVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRSVADMSYCRR 630
            |...|:||.||.|.||...|.:|||:||||.|      .:...||.||.:|:.|.:||.||..|.
Human   669 WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 733

  Fly   631 NAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSW 666
            ..||......||.|||.||.:.|.:||.|.|.::.|
Human   734 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	53/103 (51%)
		PHA03098	150..675	CDD:222983	236/529 (45%)
		BACK	258..359	CDD:285009	36/100 (36%)
		Kelch	405..449	CDD:128874	18/44 (41%)
		KELCH repeat	439..482	CDD:276965	17/42 (40%)
		Kelch	450..496	CDD:128874	20/45 (44%)
		KELCH repeat	486..530	CDD:276965	22/43 (51%)
		Kelch	497..543	CDD:128874	23/45 (51%)
		KELCH repeat	533..580	CDD:276965	25/46 (54%)
		Kelch	544..592	CDD:128874	24/47 (51%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	21/50 (42%)
		KELCH repeat	629..674	CDD:276965	16/38 (42%)
		Kelch	640..687	CDD:128874	13/27 (48%)
KLHL5	XP_011512001.1	BTB	244..347	CDD:279045	52/102 (51%)
		PHA03098	254..775	CDD:222983	233/522 (45%)
		BACK	356..455	CDD:285009	36/98 (37%)
		Kelch	503..548	CDD:128874	18/44 (41%)
		Kelch_1	537..582	CDD:279660	18/44 (41%)
		KELCH repeat	538..581	CDD:276965	17/42 (40%)
		KELCH repeat	585..629	CDD:276965	22/43 (51%)
		Kelch	598..642	CDD:128874	23/43 (53%)
		KELCH repeat	632..675	CDD:276965	24/44 (55%)
		Kelch	643..689	CDD:128874	24/47 (51%)
		Kelch_1	678..729	CDD:279660	22/50 (44%)
		KELCH repeat	679..729	CDD:276965	21/49 (43%)
		Kelch_1	732..772	CDD:279660	16/38 (42%)
		KELCH repeat	732..772	CDD:276965	16/38 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820