DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Klhl3

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	XP_038952370.1	Gene:	Klhl3 / 498697	RGDID:	1565218	Length:	601	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	344/587 - (58%)
Similarity:	440/587 - (74%)	Gaps:	12/587 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SLDESSQKHVQRPNGKERG---TVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHR 172
            |:..|.|...|..:|::..   ||    |..|..::|..|||:|.::.||||::||:|||:.|||
  Rat    19 SVKPSPQPTEQAGDGEKNRRMITV----NPAHMGKAFKVMNELRSKRLLCDVMIVAEDVEVEAHR 79

  Fly   173 MVLASCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLL 236
            :|||:|||||.|||| ...||:..:|.::.||.:.|..||||:|||.:||.|:||||||.||:||
  Rat    80 VVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLL 144

  Fly   237 QLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQ 301
            ||.|||..||||||:||..:||||||.|||:|.|.:||..|..|.||||.||:..:|||:||.:|
  Rat   145 QLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQ 209

  Fly   302 VISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLE 366
            |.|||.:|:::|.:||:|:|.||:|:.|:...|....:.||||||||.|.::|:.|.|::|.|::
  Rat   210 VCSLISSDKLTVSSEEKVFEAVISWINYEKETRLDHMAKLMEHVRLPLLPRDYLVQTVEEEALIK 274

  Fly   367 GNIVCKNLIIEALTYHLLPTE----TKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDLREE 427
            .|..||:.:|||:.|||||.:    .|:.||.||.||.:||:::|:||||||||||||.||..|.
  Rat   275 NNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEG 339

  Fly   428 KWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVA 492
            :|.|.||:|:||||:|:..:...||||||||||||||||||||...|||.:.::|:.||||||.|
  Rat   340 RWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 404

  Fly   493 VLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQ 557
            |||..:||||||||:|||:|.|.|..||:.|.|:|.|:|||||||||||.|.|||||||||.:||
  Rat   405 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQ 469

  Fly   558 CLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSV 622
            |||:||:|||.|:.|:.||:||:||||||||||:..|||.||||||:||:|||.||..||:|:.|
  Rat   470 CLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQV 534

  Fly   623 ADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDK 687
            |||:.|||||||.|.:|||||||||||:.||||||.|.|.:|.|.:||..|:.|||||||.:|.|
  Rat   535 ADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHK 599

  Fly   688 PM 689
            .:
  Rat   600 SL 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	63/103 (61%)
		PHA03098	150..675	CDD:222983	322/529 (61%)
		BACK	258..359	CDD:285009	52/100 (52%)
		Kelch	405..449	CDD:128874	26/43 (60%)
		KELCH repeat	439..482	CDD:276965	27/42 (64%)
		Kelch	450..496	CDD:128874	33/45 (73%)
		KELCH repeat	486..530	CDD:276965	28/43 (65%)
		Kelch	497..543	CDD:128874	31/45 (69%)
		KELCH repeat	533..580	CDD:276965	34/46 (74%)
		Kelch	544..592	CDD:128874	35/47 (74%)
		KELCH repeat	582..626	CDD:276965	31/43 (72%)
		Kelch	594..639	CDD:128874	31/44 (70%)
		KELCH repeat	629..674	CDD:276965	30/44 (68%)
		Kelch	640..687	CDD:128874	31/46 (67%)
Klhl3	XP_038952370.1	BTB_POZ_KLHL3	43..163	CDD:349648	70/119 (59%)
		PHA03098	64..580	CDD:222983	317/515 (62%)
		BACK_KLHL3	161..290	CDD:350588	63/128 (49%)
		KELCH repeat	311..347	CDD:276965	22/35 (63%)
		KELCH repeat	351..394	CDD:276965	27/42 (64%)
		KELCH repeat	398..442	CDD:276965	28/43 (65%)
		KELCH repeat	445..490	CDD:276965	33/44 (75%)
		KELCH repeat	494..538	CDD:276965	31/43 (72%)
		KELCH repeat	541..587	CDD:276965	31/45 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm45969
orthoMCL	1	0.900	-	-		OOG6_100281
Panther	1	1.100	-	-	O	PTHR24412
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910