Protein Alignment kel and klhl12

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001007329.1
• Gene: klhl12 / 492362
• ZFINID: ZDB-GENE-041114-205
• Length: 564
• Species: Danio rerio
• Alignment Length: 558
• Identity: 236/558 - (42%)
• Similarity: 336/558 - (60%)
• Gaps: 18/558 - (3%)

  Fly   139 HTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQARITLQSV 202
            |.....:|||.:||...|||:.|..:..:..|||:|||:||.||.||||| ..|..::.:.:|.:
Zfish    11 HAKSILNAMNALRKSNTLCDITLRVEGTDFPAHRIVLAACSDYFCAMFTSELAEKGKSFVDIQGL 75

  Fly   203 DARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADI 267
            .|..:|:|:|:|||.||.|..:|||.||.||.||||..|:.||||||.:|||.|||||||:||:.
Zfish    76 TASTMEILLDFVYTETVLVTVENVQELLPAACLLQLKGVKRACCDFLNSQLDPSNCLGIRDFAET 140

  Fly   268 HACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVP 332
            |.|::|:..||.:.::||.||:|.:||:.||..:|..||..|.|.|.:||.|:|.|:.|::::..
Zfish   141 HNCLDLMQAAELFSQKHFAEVVQQEEFMLLSQSEVEKLIKCDVIQVDSEEPVFEAVLNWVKHNRK 205

  Fly   333 MREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLP---TETKSARTV 394
            .||.:...|:|:||:|.|:..|||..:|.|.|:..::.|::|:.||..:||.|   :|.:|.||.
Zfish   206 EREPYLPDLLEYVRMPLLTPRYITDVIDAEPLIRCSLPCRDLVDEAKKFHLRPELRSEMQSPRTQ 270

  Fly   395 PRKPVGMPKILLVIGG----QAPKAIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVG 455
            .|  :|..::||||||    |:|  |..||.||.:..:|.....:..:|.......|.|:||.:|
Zfish   271 AR--LGAKEVLLVIGGFGSQQSP--IDIVEKYDPKTREWSFLPNIARKRRYVATVALNDRVYVIG 331

  Fly   456 GFNGSLRVRTVDVYDPATDQ---WANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYD 517
            |::|..|:.:|:..|...|:   |.:.:.|..||...|...|...||..|||||:...:|.|.||
Zfish   332 GYDGRSRLSSVECLDYTADEDGVWYSVATMNVRRGLAGATTLGDMIYVAGGFDGSRRHTSMERYD 396

  Fly   518 PKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRR 582
            |..|.|..:..|.|.|...|:.|..||:|.:|||||.  ..|:|||||:|.|..|.:|..|:::|
Zfish   397 PNIDQWSMLGDMQTAREGAGLVVASGLIYCLGGYDGL--NILNSVERYDPHTGHWTSVTPMANKR 459

  Fly   583 SGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGD 647
            |||||.:||:.:|.|||.||.....|||.|:..|:.|.:||:|:..|...|.....|.||.:.|.
Zfish   460 SGAGVALLNDHIYVVGGFDGTAHLSSVEVYNIRTDYWTTVANMTTPRCYVGATVLRGRLYAIAGY 524

  Fly   648 DGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMI 685
            ||.|.|:|:|.|.|..|||.::.::.| .|..||||::
Zfish   525 DGNSLLSSIECYDPVIDSWEVVTSMAT-QRCDAGVCVL 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	57/116 (49%)
		PHA03098	150..675	CDD:222983	226/535 (42%)
		KELCH repeat	439..482	CDD:276965	13/45 (29%)
		KELCH repeat	486..530	CDD:276965	17/43 (40%)
		KELCH repeat	533..580	CDD:276965	22/46 (48%)
		KELCH repeat	582..626	CDD:276965	22/43 (51%)
		KELCH repeat	629..674	CDD:276965	17/44 (39%)
klhl12	NP_001007329.1	BTB_POZ_KLHL12_C3IP1_DKIR	8..131	CDD:349551	59/119 (50%)
		BACK_KLHL12	126..261	CDD:350527	58/134 (43%)
		Kelch	278..325	CDD:128874	16/48 (33%)
		Kelch 1	278..325		16/48 (33%)
		NanM	304..561	CDD:442289	103/259 (40%)
		KELCH repeat	315..361	CDD:276965	13/45 (29%)
		Kelch 2	327..375		15/47 (32%)
		KELCH repeat	365..408	CDD:276965	17/42 (40%)
		Kelch 3	376..422		19/45 (42%)
		KELCH repeat	412..455	CDD:276965	21/44 (48%)
		Kelch 4	423..469		25/47 (53%)
		KELCH repeat	459..503	CDD:276965	22/43 (51%)
		Kelch 5	471..516		17/44 (39%)
		KELCH repeat	506..551	CDD:276965	17/44 (39%)
		Kelch 6	518..563		20/45 (44%)