DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Keap1

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	235/744 - (31%)
Similarity:	347/744 - (46%)	Gaps:	113/744 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 GQYSNEQHTARSFDAMNE-------------------MRKQKQLCDVILVADDVEIHAHRMVLAS 177
            |::.:...|....||.::                   ||....|.||:|........||::||::
  Fly    46 GRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSA 110

  Fly   178 CSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDV 241
            .||||.|||| ..:||..:|:.||.|...|:..::.::||..:.|.|..|..||.||.:.|:.:|
  Fly   111 ASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNV 175

  Fly   242 RDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLI 306
            .||||.||:.|||.:|.:||..||:.|.||||...|..:||::|.:|.|.:|||.||..|:|:||
  Fly   176 IDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALI 240

  Fly   307 GNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEH----VRLPFLSKEYITQRVDKEILLEG 367
            ..|.::|..|..||..|:.|::||    |......|||    ||..||:..::.:::....:|..
  Fly   241 RRDELNVQEEREVYNAVLKWVKYD----EDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRK 301

  Fly   368 NIVCKNL---IIEALTYHLLPTETKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDLREEKW 429
            ...|:..   |.:.||.|..|       .|..:.....:::.|.||....::..:|.|::.:..|
  Fly   302 VPACREYLAKIFKDLTLHKCP-------GVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTW 359

  Fly   430 YQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVR----TVDVYDPATDQWANCSNMEARRSTLG 490
            ...|.:...|...|.:.|..|.|||||.|.::...    .||.|...|:.|..|:.|...|..:|
  Fly   360 TTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVG 424

  Fly   491 VAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFT 555
            |||::..:|||||..|....::.|.|||..|.|..:..|..:|..|||.||:.||||:||:||..
  Fly   425 VAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNE 489

  Fly   556 RQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWR 620
            |  |:|||.|:|:.:.|..:..:.:.||||||..:|..:|.|||.||.....:||.||.|.::|.
  Fly   490 R--LASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWD 552

  Fly   621 SVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMI 685
            .||.:...|....:...|..||.:||.||.:.|:.||||.|.:::|.....|.: |||.....:|
  Fly   553 MVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKS-GRSGHASAVI 616

  Fly   686 DKPMXMEEQGALARQAASLAIALLDDENSQA---EGTMEGAIGGAIYGNLAPAGGAAAAAAPAAP 747
            .:|              :.:...:|.|:|.|   :|:..|                      ...
  Fly   617 YQP--------------ACSTTFMDYEDSDAPHPDGSNNG----------------------ERN 645

  Fly   748 AQAPQPNH----PHYE------NIYAPIGQPSNNNNNS----------GSNSNQAAAI-----AN 787
            |..||..:    |||.      ..:...|....||.:|          ..:|.|..||     .|
  Fly   646 AHTPQNTYGSGSPHYPGTASNMQFHTSYGMSGCNNCDSEMDIKPYIPAEHHSFQIPAIRSEELVN 710

  Fly   788 ANAP-ANAEEIQQQQQPA---PTEPNANN 812
            .|.| :..:|..::..||   ..|.|||:
  Fly   711 PNCPWSRMQERFRRTPPASFTDDERNAND 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	41/122 (34%)
		PHA03098	150..675	CDD:222983	196/536 (37%)
		BACK	258..359	CDD:285009	41/104 (39%)
		Kelch	405..449	CDD:128874	10/43 (23%)
		KELCH repeat	439..482	CDD:276965	16/46 (35%)
		Kelch	450..496	CDD:128874	19/49 (39%)
		KELCH repeat	486..530	CDD:276965	17/43 (40%)
		Kelch	497..543	CDD:128874	19/45 (42%)
		KELCH repeat	533..580	CDD:276965	22/46 (48%)
		Kelch	544..592	CDD:128874	22/47 (47%)
		KELCH repeat	582..626	CDD:276965	21/43 (49%)
		Kelch	594..639	CDD:128874	15/44 (34%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)
		Kelch	640..687	CDD:128874	18/46 (39%)
Keap1	NP_732202.2	BTB	80..183	CDD:279045	40/102 (39%)
		PHA03098	92..599	CDD:222983	190/519 (37%)
		BACK	192..294	CDD:285009	41/105 (39%)
		Kelch	335..379	CDD:128874	10/43 (23%)
		KELCH repeat	369..416	CDD:276965	16/46 (35%)
		Kelch	382..430	CDD:128874	18/47 (38%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		Kelch	433..476	CDD:128874	18/42 (43%)
		KELCH repeat	467..510	CDD:276965	22/44 (50%)
		Kelch	478..523	CDD:128874	22/46 (48%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		Kelch_1	514..556	CDD:279660	20/41 (49%)
		KELCH repeat	561..606	CDD:276965	16/44 (36%)
		Kelch	572..616	CDD:128874	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464356
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26788at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	8	7.850