Protein Alignment kel and Keap1

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Alignment Length: 744
• Identity: 235/744 - (31%)
• Similarity: 347/744 - (46%)
• Gaps: 113/744 - (15%)

  Fly   132 GQYSNEQHTARSFDAMNE-------------------MRKQKQLCDVILVADDVEIHAHRMVLAS 177
            |::.:...|....||.::                   ||....|.||:|........||::||::
  Fly    46 GRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSA 110

  Fly   178 CSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDV 241
            .||||.|||| ..:||..:|:.||.|...|:..::.::||..:.|.|..|..||.||.:.|:.:|
  Fly   111 ASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNV 175

  Fly   242 RDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLI 306
            .||||.||:.|||.:|.:||..||:.|.||||...|..:||::|.:|.|.:|||.||..|:|:||
  Fly   176 IDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALI 240

  Fly   307 GNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEH----VRLPFLSKEYITQRVDKEILLEG 367
            ..|.::|..|..||..|:.|::||    |......|||    ||..||:..::.:::....:|..
  Fly   241 RRDELNVQEEREVYNAVLKWVKYD----EDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRK 301

  Fly   368 NIVCKNL---IIEALTYHLLPTETKSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDLREEKW 429
            ...|:..   |.:.||.|..|       .|..:.....:::.|.||....::..:|.|::.:..|
  Fly   302 VPACREYLAKIFKDLTLHKCP-------GVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTW 359

  Fly   430 YQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVR----TVDVYDPATDQWANCSNMEARRSTLG 490
            ...|.:...|...|.:.|..|.|||||.|.::...    .||.|...|:.|..|:.|...|..:|
  Fly   360 TTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVG 424

  Fly   491 VAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFT 555
            |||::..:|||||..|....::.|.|||..|.|..:..|..:|..|||.||:.||||:||:||..
  Fly   425 VAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNE 489

  Fly   556 RQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWR 620
            |  |:|||.|:|:.:.|..:..:.:.||||||..:|..:|.|||.||.....:||.||.|.::|.
  Fly   490 R--LASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWD 552

  Fly   621 SVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMI 685
            .||.:...|....:...|..||.:||.||.:.|:.||||.|.:::|.....|.: |||.....:|
  Fly   553 MVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKS-GRSGHASAVI 616

  Fly   686 DKPMXMEEQGALARQAASLAIALLDDENSQA---EGTMEGAIGGAIYGNLAPAGGAAAAAAPAAP 747
            .:|              :.:...:|.|:|.|   :|:..|                      ...
  Fly   617 YQP--------------ACSTTFMDYEDSDAPHPDGSNNG----------------------ERN 645

  Fly   748 AQAPQPNH----PHYE------NIYAPIGQPSNNNNNS----------GSNSNQAAAI-----AN 787
            |..||..:    |||.      ..:...|....||.:|          ..:|.|..||     .|
  Fly   646 AHTPQNTYGSGSPHYPGTASNMQFHTSYGMSGCNNCDSEMDIKPYIPAEHHSFQIPAIRSEELVN 710

  Fly   788 ANAP-ANAEEIQQQQQPA---PTEPNANN 812
            .|.| :..:|..::..||   ..|.|||:
  Fly   711 PNCPWSRMQERFRRTPPASFTDDERNAND 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	47/138 (34%)
		PHA03098	150..675	CDD:222983	196/536 (37%)
		KELCH repeat	439..482	CDD:276965	16/46 (35%)
		KELCH repeat	486..530	CDD:276965	17/43 (40%)
		KELCH repeat	533..580	CDD:276965	22/46 (48%)
		KELCH repeat	582..626	CDD:276965	21/43 (49%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	190/519 (37%)
		KELCH repeat	369..416	CDD:276965	16/46 (35%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	22/44 (50%)
		KELCH repeat	514..558	CDD:276965	21/43 (49%)
		KELCH repeat	561..606	CDD:276965	16/44 (36%)