DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kel and CG15097

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001261079.1	Gene:	CG15097 / 37172	FlyBaseID:	FBgn0034396	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	274/734 - (37%)
Similarity:	388/734 - (52%)	Gaps:	35/734 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NPAAEGSGLERGSCLLRYASQNSLDESSQKHVQRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQ 153
            |.:.|.||....   :...|.||....|......|| :|......:.|..|...||.|:|:||..
  Fly     8 NHSGEASGNNED---VTTTSNNSTQTPSDLSPPGPN-EEVLPQAHHQNPGHCIASFAAINQMRNN 68

  Fly   154 KQLCDVILVADDVEIHAHRMVLASCSPYFYAMFT-SFEESRQARITLQSVDARALELLIDYVYTA 217
            .|||||.|......|:|||:||||.||||||||. ...|..|..:.|..||:.||..||||.||.
  Fly    69 AQLCDVRLEVGGDTINAHRVVLASVSPYFYAMFNDDMLERTQGLVRLHDVDSSALRQLIDYTYTG 133

  Fly   218 TVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELLNYAETYIE 282
            .:.:.|.||||||.|:.|||:..||||||.||..||..|||||||.|||.|:|.||...:..|..
  Fly   134 EITITEQNVQVLLPASGLLQMHSVRDACCKFLLRQLHPSNCLGIRSFADAHSCKELHTRSHKYAL 198

  Fly   283 QHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMREQFTSLLMEHVRL 347
            |:|.:|:..:|||.|..|:|..||.|.::::.:||||:..||.|:::|:|.|....:.||.:|||
  Fly   199 QNFQQVVGTEEFLLLPFEEVRELISNSQLNISSEERVFAAVINWVKHDLPTRRLHIAELMSNVRL 263

  Fly   348 PFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTETK---SARTVPRKPVGMPKILLVIG 409
            |.:|::::...|:.|.|:..:..||.|::||:.|||||.:..   |.||..|:|.||...:..:|
  Fly   264 PLVSRDFLMSCVETETLMRDDSECKELLLEAMKYHLLPEQRSIMGSQRTQERRPEGMKPYVFAVG 328

  Fly   410 GQAPKAIRS-VEWYDLREEKWYQAAEMPNRRCRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPAT 473
            |.:..||.: .|.|:.|...|...|.|..||.|||::.|..::|.|||::|...:.|.:.|:|.|
  Fly   329 GGSLFAIHNECEVYNPRSNSWSPVAPMLWRRSRSGVTSLHKQLYVVGGYDGVSDLATAESYNPLT 393

  Fly   474 DQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGV 538
            ::|:|.:.|..:||.||:...:..||..||:||.:.|||.|.|||.|.||....:|||||....:
  Fly   394 NKWSNITPMGTKRSCLGICSYDALIYVCGGYDGASCLSSMERYDPLTGIWSSCPAMSTRRRYCRL 458

  Fly   539 GVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP 603
            .|:...:|::||:|....|  |||||::|....|..|..||:|||..||...:..||.:||:||.
  Fly   459 AVLENCIYSLGGFDSTNYQ--SSVERFDPRVGRWQPVPSMSARRSSCGVASTDGHLYCIGGNDGT 521

  Fly   604 MVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWRI 668
            |...|.|.:....|||..:|.|...|....||..:|.|:.:||:||:|:|.|||.|....:.|.:
  Fly   522 MCMSSGERFSLRRNSWEPIAAMHSRRSTHEVVEVEGALFALGGNDGSSSLNSVERYDTRLNKWSV 586

  Fly   669 LPALMTIGRSYAGVCMID---------KPMXMEEQGALARQAASLAIALLDDENSQAEGTMEGAI 724
            :.| |...||..|..:::         :.. :....::....|:.|.:...:.||...|...|.:
  Fly   587 VNA-MVARRSSVGAAVLECFHLERGLVQTTNLXPLASITESFAAAAASGTSNGNSTINGIGSGGV 650

  Fly   725 ---GGAIYGNLAPAGGAAAAA-------APAAP-AQAPQPNHPHYENIYAPIGQPSNNNNNSGSN 778
               ...:.|.|.....|.|||       :.:|| |.:....|.......|...:.::|.::|||.
  Fly   651 IPSSSGVGGTLTVPSRAEAAAFTANIALSSSAPSASSTLRRHRRDTPGLAESRRANSNASSSGSE 715

  Fly   779 SNQ---AAAIANANAPANA 794
            |..   |:.......||.|
  Fly   716 SGSTSGASGSGGGKPPATA 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	56/103 (54%)
		PHA03098	150..675	CDD:222983	228/529 (43%)
		BACK	258..359	CDD:285009	42/100 (42%)
		Kelch	405..449	CDD:128874	16/44 (36%)
		KELCH repeat	439..482	CDD:276965	16/42 (38%)
		Kelch	450..496	CDD:128874	16/45 (36%)
		KELCH repeat	486..530	CDD:276965	20/43 (47%)
		Kelch	497..543	CDD:128874	22/45 (49%)
		KELCH repeat	533..580	CDD:276965	16/46 (35%)
		Kelch	544..592	CDD:128874	20/47 (43%)
		KELCH repeat	582..626	CDD:276965	17/43 (40%)
		Kelch	594..639	CDD:128874	17/44 (39%)
		KELCH repeat	629..674	CDD:276965	17/44 (39%)
		Kelch	640..687	CDD:128874	17/55 (31%)
CG15097	NP_001261079.1	BTB	63..166	CDD:279045	56/102 (55%)
		PHA03098	65..539	CDD:222983	208/475 (44%)
		BACK	174..276	CDD:285009	42/101 (42%)
		Kelch	324..369	CDD:128874	16/44 (36%)
		KELCH repeat	359..402	CDD:276965	16/42 (38%)
		Kelch	370..415	CDD:128874	16/44 (36%)
		KELCH repeat	406..450	CDD:276965	20/43 (47%)
		Kelch	417..463	CDD:128874	22/45 (49%)
		KELCH repeat	453..496	CDD:276965	15/44 (34%)
		Kelch	464..510	CDD:128874	20/47 (43%)
		Kelch_1	499..543	CDD:279660	18/43 (42%)
		KELCH repeat	500..545	CDD:276965	18/44 (41%)
		KELCH repeat	547..590	CDD:276965	17/43 (40%)
		Kelch	559..603	CDD:128874	17/44 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464361
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D26788at33392
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850