DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and klhl41b

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_945330.1	Gene:	klhl41b / 321064	ZFINID:	ZDB-GENE-030131-9875	Length:	605	Species:	Danio rerio

Alignment Length:	574	Identity:	137/574 - (23%)
Similarity:	241/574 - (41%)	Gaps:	98/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 DAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTSFEESRQ----ARITLQSVDAR 205
            |.:.|:..:.:..|..|...|.....||:::|:|||||..:|.| |:.::    ..:.|..||..
Zfish    20 DGLKELLNENKFVDCTLKIGDRCFPCHRLIMAACSPYFRELFFS-EDGKEKDIGKEVVLDDVDPN 83

  Fly   206 ALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHAC 270
            .:::::.|:|:|.:::.:||||.:...||..|:..|...|.::||.:|..:|||.:.....:.:.
Zfish    84 IMDMILQYLYSAEIDLVDDNVQEIFAVANRFQIPSVFTVCVNYLQQKLSMANCLAVFRLGLVLSV 148

  Fly   271 VELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLRYDVPMRE 335
            ..|...|..:|...|..|...:|||.|:..::.:|||.|.::|..||.|:|.|:.|:|.|...|.
Zfish   149 PRLAIAARDFIADRFETVSSEEEFLQLAPHELSALIGGDMLNVEKEEVVFESVMKWVRNDKANRV 213

  Fly   336 QFTSLLMEHVRLPFLSKEYITQRVDKEILLEGN-------------------------------- 368
            :..:...:.:|...|.::|..::|:.:.:::|:
Zfish   214 KSLAEAFDCIRFRLLPEKYFREKVETDDIIKGDPELLKKLQLVKDAFKGKLPKKKPKEKKEGEVN 278

  Fly   369 --------------------IVCKNLII-----EALTYHLLPTE---TKSARTVPRKPVGM---P 402
                                :..::||:     .|:.|.::..|   ...|..||:..|.:   .
Zfish   279 GEEEGEEMLPGFLNDNRRLGMYGRDLIVMINDTAAVAYDVVENECFLAAMAEQVPKNHVSLCTKK 343

  Fly   403 KILLVIGG-----QAPKAIRSVEWYDLR--EEKWYQAAEMPNRRCRSGLSVLGDKVYAVGG---- 456
            ..|.::||     ::.::.....:|.|.  ...|.....||:.||...|....:.::|:.|
Zfish   344 NQLFIVGGLFVDEESKESPLQCYFYQLDSFSSDWRALPPMPSPRCLFNLGESENLLFAIAGKDLQ 408

  Fly   457 FNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGG-FDGTTGLSSAEMYDPKT 520
            .|.||  .:|..:|....:|:....:........|...|..:|.:|| .|....||...:|:.|.
Zfish   409 TNESL--DSVMCFDTERMKWSETKKLPLHIHGHSVVSHNNLVYCIGGKTDDNKALSKMFVYNHKQ 471

  Fly   521 DIWRFIASMSTRRSSVGVGVVHGLLYAVGGY--DGFTRQCLSSVERYNPDTDTWVNVAEMSSRRS 583
            ..||.:|||.|.|:..|..|..|.:...||.  ||.|  .||  |.|:.||:.|....|....||
Zfish   472 SEWRELASMKTPRAMFGAVVHKGKIIVTGGVNEDGLT--ALS--ETYDFDTNKWDTFTEFPQERS 532

  Fly   584 GAGVGVLNNILYAVGG---------HDGPMVRRSVEAYDCETNSWRS-VADMSY 627
            ...:......|:::||         :.||.....:..|:.:..:|.. :.:|.|
Zfish   533 SVNLVSSGGNLFSIGGFAIVELEDKNIGPSEITDIWQYEEDKKTWSGMLREMRY 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	30/106 (28%)
		PHA03098	150..675	CDD:222983	135/569 (24%)
		BACK	258..359	CDD:285009	28/100 (28%)
		Kelch	405..449	CDD:128874	11/50 (22%)
		KELCH repeat	439..482	CDD:276965	11/46 (24%)
		Kelch	450..496	CDD:128874	9/49 (18%)
		KELCH repeat	486..530	CDD:276965	14/44 (32%)
		Kelch	497..543	CDD:128874	17/46 (37%)
		KELCH repeat	533..580	CDD:276965	17/48 (35%)
		Kelch	544..592	CDD:128874	15/49 (31%)
		KELCH repeat	582..626	CDD:276965	9/53 (17%)
		Kelch	594..639	CDD:128874	9/44 (20%)
		KELCH repeat	629..674	CDD:276965
		Kelch	640..687	CDD:128874
klhl41b	NP_945330.1	BTB	22..128	CDD:279045	30/106 (28%)
		PHA03098	46..528	CDD:222983	121/488 (25%)
		BACK	136..238	CDD:285009	28/101 (28%)
		Kelch 1. /evidence=ECO:0000255	345..397		11/51 (22%)
		KELCH repeat	387..432	CDD:276965	11/46 (24%)
		Kelch 2. /evidence=ECO:0000255	398..446		9/49 (18%)
		KELCH repeat	436..481	CDD:276965	14/44 (32%)
		Kelch_6	437..484	CDD:290672	16/46 (35%)
		Kelch 3. /evidence=ECO:0000255	447..494		17/46 (37%)
		Kelch_1	483..521	CDD:279660	15/41 (37%)
		KELCH repeat	484..529	CDD:276965	17/48 (35%)
		Kelch 4. /evidence=ECO:0000255	496..541		15/48 (31%)
		KELCH repeat	531..578	CDD:276965	8/46 (17%)
		Kelch 5. /evidence=ECO:0000255	543..598		9/44 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810