DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kel and Klhl4

DIOPT Version :9

Sequence 1:	NP_476589.4	Gene:	kel / 35084	FlyBaseID:	FBgn0001301	Length:	1477	Species:	Drosophila melanogaster
Sequence 2:	NP_001101714.1	Gene:	Klhl4 / 317196	RGDID:	1565441	Length:	717	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	260/708 - (36%)
Similarity:	380/708 - (53%)	Gaps:	57/708 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNLSNGNSNNNN--QQQQQQQQGQNPQQPAQN-----------EGGAGAEFVAPPPGLGAAVGVA 68
            |:.|.|:.|..:  ||:..:.:|...|...:|           ......:.:.|.||
  Rat    23 SHPSQGSPNTGSCLQQEGYEHRGTPVQGRLKNHSRDRNGLKKSNSPVHHDILTPVPG-------- 79

  Fly    69 AMQQRNRLLQQQQQQH---HHHQN---PAA--EGSGL-----ERGSCLLRYASQNSLDESSQKHV 120
            ......|:||...||:   |...|   |.|  ||:.|     :|...|......|..|..::::.
  Rat    80 PAPTHQRVLQNWHQQNVIVHLQANEDTPKAVPEGNLLKEACEKRARDLEMMGDDNIEDSRARQYA 144

  Fly   121 QRPNGKERGTVGQYSNEQHTARSFDAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAM 185
            :.|......:...|.:..|...:...|....|:|:||||:|:|..::|.|||:||::.|.||.||
  Rat   145 EEPEQMNVISEDHYRSRNHADYTLCKMESYLKEKKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAM 209

  Fly   186 FTS-FEESRQARITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFL 249
            ||: ..|:||..:.::.||..||..|:.|.||..:::.||.::.||:||.|||||.|.|.||:||
  Rat   210 FTNDVLEARQEEVKMEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFL 274

  Fly   250 QTQLDASNCLGIREFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVP 314
            ..||..|||||||.|.|...|:||.|.|..|..:||.:|::..|||.|...::..|:.:|.|:||
  Rat   275 IKQLHPSNCLGIRSFGDAQGCMELQNVAHKYTMEHFIDVVKNQEFLLLPANEISKLLCSDDINVP 339

  Fly   315 NEERVYECVIAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEAL 379
            :||.::..::.|:.:|...|:|..:.|:.::|||.||.:.:.. ::...:..|::.|:.|::||:
  Rat   340 DEETIFHALMQWVGHDAQARQQDLAKLLSYIRLPLLSPQLLAD-LENSSMFSGDLECQKLLMEAM 403

  Fly   380 TYHLLP---TETKSARTVPRK-PVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQAAEMPNRR 439
            .|||||   :..:|.||.||| .||   .|..:|| .|.|...::|.||||...|.....|..||
  Rat   404 KYHLLPERRSMLQSPRTKPRKSTVG---ALYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSGRR 465

  Fly   440 CRSGLSVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGF 504
            .:.|::|:.:|:|.|||.:|...:.||:.::|.|..|.....|...|..||||.|.|.:|||||.
  Rat   466 LQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGH 530

  Fly   505 DGTTGLSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDT 569
            ||.:.|::.|.:||....|.::|||||.||:|||..::..|||:||.||  ..||.|:|.::|.|
  Rat   531 DGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG--SSCLKSMEYFDPHT 593

  Fly   570 DTWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGP------MVRRSVEAYDCETNSWRSVADMSYC 628
            :.|...|.||.||.|.||...|..||.|||||.|      .:...||.||.:::||.:||.:|..
  Rat   594 NKWSLCAPMSKRRGGVGVATHNGYLYVVGGHDAPAPNHCSRLSDCVERYDPKSDSWSTVAPLSVP 658

  Fly   629 RRNAGVVAHDGLLYVVGGDDGTSNLASVEVYCPDSDSWR-ILPALMTIGRSYAGVCMI 685
            |....|......||||||.||.:.|.:||.|....|.|: .:|  :.|||  ||.|::
  Rat   659 RDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWKEEVP--VNIGR--AGACVV 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB	147..250	CDD:279045	49/103 (48%)
		PHA03098	150..675	CDD:222983	222/537 (41%)
		BACK	258..359	CDD:285009	37/100 (37%)
		Kelch	405..449	CDD:128874	16/44 (36%)
		KELCH repeat	439..482	CDD:276965	14/42 (33%)
		Kelch	450..496	CDD:128874	18/45 (40%)
		KELCH repeat	486..530	CDD:276965	21/43 (49%)
		Kelch	497..543	CDD:128874	22/45 (49%)
		KELCH repeat	533..580	CDD:276965	21/46 (46%)
		Kelch	544..592	CDD:128874	22/47 (47%)
		KELCH repeat	582..626	CDD:276965	21/49 (43%)
		Kelch	594..639	CDD:128874	19/50 (38%)
		KELCH repeat	629..674	CDD:276965	17/45 (38%)
		Kelch	640..687	CDD:128874	21/47 (45%)
Klhl4	NP_001101714.1	BTB	171..275	CDD:279045	49/103 (48%)
		PHA03098	175..697	CDD:222983	220/527 (42%)
		BACK	283..382	CDD:285009	37/98 (38%)
		Kelch	430..475	CDD:128874	16/44 (36%)
		Kelch_1	464..509	CDD:279660	15/44 (34%)
		KELCH repeat	465..508	CDD:276965	14/42 (33%)
		KELCH repeat	512..556	CDD:276965	21/43 (49%)
		Kelch	525..569	CDD:128874	22/43 (51%)
		KELCH repeat	559..602	CDD:276965	20/44 (45%)
		Kelch	570..616	CDD:128874	22/47 (47%)
		Kelch_1	605..656	CDD:279660	22/50 (44%)
		KELCH repeat	606..657	CDD:276965	21/50 (42%)
		KELCH repeat	659..698	CDD:276965	16/38 (42%)
		Kelch	670..714	CDD:128874	21/47 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820