DRSC/TRiP Functional Genomics Resources

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Protein Alignment kel and Klhl40

DIOPT Version :9

Sequence 1:NP_476589.4 Gene:kel / 35084 FlyBaseID:FBgn0001301 Length:1477 Species:Drosophila melanogaster
Sequence 2:NP_001101665.2 Gene:Klhl40 / 316088 RGDID:1305368 Length:621 Species:Rattus norvegicus


Alignment Length:603 Identity:138/603 - (22%)
Similarity:226/603 - (37%) Gaps:167/603 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 DAMNEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTSFEESRQARITLQSVDARALEL 209
            |.:.:|....:..|.::...:.|...||:|||:|||||.|.|.: |......:.|:.|....:..
  Rat    21 DGLKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLA-EPDGAGELRLEEVSPDVVSQ 84

  Fly   210 LIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGIREFADIHACVELL 274
            ::.|:||:.:.::|.:||.|..||:..|:..:...|..|||.:|..:|||.:.....:..|..|.
  Rat    85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLDCARLA 149

  Fly   275 NYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAWLR---YDVPMREQ 336
            ..|..:|...|..|.:.::||.||.:::|::|.:|.::|..||.|:|.|:.|..   .||....|
  Rat   150 VAARDFICARFPLVARDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWASSGDADVQAEHQ 214

  Fly   337 -FTSLLMEHVRLPFLSKEYITQRVDKEILL-----------------EGNI-------------- 369
             ....:.|.:|...|.:.::..||::..|:                 ||.:              
  Rat   215 RALPTVFESIRCRLLPRAFLESRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRKKKKEKGEQT 279

  Fly   370 ---------------------VCKNLIIEALTYHLL-----------------PTETKS-----A 391
                                 |...::.:.|.:.:.                 |...:.     :
  Rat   280 ARTKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLS 344

  Fly   392 RTVPRKPV-----------------------------------------GMPKI----------- 404
            ..:|:..|                                         |||.:           
  Rat   345 TQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGE 409

  Fly   405 ----LLVIGGQAPK----AIRSVEWYDLREEKWYQAAEMPNRRCRSGLSVLG--DKVYAVGGFNG 459
                :.|:||:..|    ::.||..||....||.::..:|  ....|.|||.  |.||.:|| .|
  Rat   410 ALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLP--YAVYGHSVLSHMDLVYVIGG-KG 471

  Fly   460 SLR--VRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLSSAEMYDPKTDI 522
            ..|  :..:.||||...:|...:.|:..||..|..|.:|.|:...|...|...||.|:|....:.
  Rat   472 KDRKCLNKMCVYDPKKFEWKELAPMKTARSLFGATVHDGRIFVAAGVTDTGLTSSTEVYSIADNK 536

  Fly   523 WRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQC-------LSSVERYNPDTDTWVNVAEMSS 580
            |....:....|||:.:..:.|.|||:||:.....:.       |:.:.|:|.|...|        
  Rat   537 WTPFEAFPQERSSLSLVSLAGTLYALGGFATLETESGELVPTELNDIWRFNEDEKKW-------- 593

  Fly   581 RRSGAGVGVLNNILYAVG 598
                  .|||..|.||.|
  Rat   594 ------EGVLREIAYAAG 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kelNP_476589.4 BTB 147..250 CDD:279045 30/102 (29%)
PHA03098 150..675 CDD:222983 137/598 (23%)
BACK 258..359 CDD:285009 28/104 (27%)
Kelch 405..449 CDD:128874 15/49 (31%)
KELCH repeat 439..482 CDD:276965 16/46 (35%)
Kelch 450..496 CDD:128874 16/47 (34%)
KELCH repeat 486..530 CDD:276965 13/43 (30%)
Kelch 497..543 CDD:128874 11/45 (24%)
KELCH repeat 533..580 CDD:276965 14/53 (26%)
Kelch 544..592 CDD:128874 13/54 (24%)
KELCH repeat 582..626 CDD:276965 7/17 (41%)
Kelch 594..639 CDD:128874 3/5 (60%)
KELCH repeat 629..674 CDD:276965
Kelch 640..687 CDD:128874
Klhl40NP_001101665.2 BTB_POZ 6..137 CDD:365784 37/116 (32%)
PHA03098 47..594 CDD:222983 127/564 (23%)
KELCH repeat 351..398 CDD:276965 4/46 (9%)
KELCH repeat 402..448 CDD:276965 10/45 (22%)
KELCH repeat 452..497 CDD:276965 16/45 (36%)
KELCH repeat 500..545 CDD:276965 13/44 (30%)
KELCH repeat 547..594 CDD:276965 14/60 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X9
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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