Protein Alignment kel and Klhl23

DIOPT Version :10

• Sequence 1: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Sequence 2: NP_001127976.1
• Gene: Klhl23 / 311114
• RGDID: 1307166
• Length: 596
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 181/570 - (31%)
• Similarity: 260/570 - (45%)
• Gaps: 50/570 - (8%)

  Fly   134 YSNEQHTARSFDAMNEMRKQKQLCDVIL-VADDVEIHAHRMVLASCSPYFYAMFTS-FEESRQAR 196
            :.:..|.....||...........|:.| ....:..|.||.|||:||.||.||||: .:|..:::
  Rat    13 FKDSSHPVDFLDAFRTFYMDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSK 77

  Fly   197 ITLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCLGI 261
            |.|..:....||.|::|.||:.:|:.:.|||.||.||:|||...|:.||..||...||..||:|:
  Rat    78 IKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGM 142

  Fly   262 REFADIHACVELLNYAETYIEQHFNEVIQFDEFLNLSHEQVISLIGNDRISVPNEERVYECVIAW 326
            ..||:.|.|.||...:...:...|.||.|.:|||.:|.|:.:.::....:||..||.:.|.||.|
  Rat   143 HSFAEFHVCSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKW 207

  Fly   327 LRYDVPMREQFTSLLMEHVRL---PFLSKEYITQRVDKEILLEGNIVCKNLIIEALTYHLLPTET 388
            ..:||..|.:....|:.:|.:   |...|..:  .:.:..||..|.: ::||..||.........
  Rat   208 TAHDVENRVECLYNLLSYVNIDIDPVYLKTAL--GLQRSCLLTENKI-RSLIYNALNPMHKEISQ 269

  Fly   389 KSARTVPRKPVGMPKILLVIGGQAPKAIRSVEWYDLREEKWYQAAEMPNRRCRS-GLSVLGDKVY 452
            :|..|           :.:|||.....:..|..:|.....|.|.||:|:....| |::.||..:|
  Rat   270 RSTAT-----------MYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIY 323

  Fly   453 AVGGFNGSLRVRTVD------VYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTGLS 511
            ..||:    |...:|      :|:...|:|.....|...|.......|.||:||:||:.......
  Rat   324 VTGGY----RTDNIDALDTVWIYNSEGDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAE 384

  Fly   512 SAEMYDPKTDIWRFIASMSTRRSSVGVG-----VVHGLLYAVGGYDGFTRQC-LSSVERYNPDTD 570
            .||.|||..:.|..||:|..     |||     |:|.::|.:||:.|:...| ...|:.||.|.:
  Rat   385 EAEFYDPLKEKWLPIANMIK-----GVGNATACVLHEVIYVIGGHCGYRGSCTYDKVQSYNSDIN 444

  Fly   571 TWVNVAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVV 635
            .|..:........|.......|.||.|||.     ....|.||.|.|.||..|.|...|...|.|
  Rat   445 EWSLITASPHPEYGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWRETAPMMERRMECGAV 504

  Fly   636 AHDGLLYVVGG---DDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGV 682
            ..:|.:||.||   ..|| .|.|:|.|.||.:.|.|:..|.:..||:..|
  Rat   505 IMNGCIYVTGGYSYSKGT-YLQSIEKYDPDLNKWEIVGNLPSAMRSHGCV 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	45/120 (38%)
		PHA03098	150..675	CDD:222983	175/545 (32%)
		KELCH repeat	439..482	CDD:276965	12/49 (24%)
		KELCH repeat	486..530	CDD:276965	16/43 (37%)
		KELCH repeat	533..580	CDD:276965	15/52 (29%)
		KELCH repeat	582..626	CDD:276965	15/43 (35%)
		KELCH repeat	629..674	CDD:276965	19/47 (40%)
Klhl23	NP_001127976.1	BTB_POZ_KLHL23	15..141	CDD:349561	48/125 (38%)
		PHA03098	45..545	CDD:222983	173/528 (33%)
		BACK_KLHL23	134..235	CDD:350537	34/100 (34%)
		KELCH repeat	310..355	CDD:276965	12/48 (25%)
		KELCH repeat	359..402	CDD:276965	16/42 (38%)
		KELCH repeat	406..495	CDD:276965	29/93 (31%)
		KELCH repeat	498..545	CDD:276965	19/47 (40%)